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Targeting BKCa Channels in Migraine: Rationale and Perspectives

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  1. Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

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  2. Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

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  3. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review

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  4. Monoclonal Antibodies for Relapsing Multiple Sclerosis: A Review of Recently Marketed and Late-Stage Agents

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  1. Ictal neck pain investigated in the interictal state - a search for the origin of pain

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  2. Neck pain and headache after whiplash injury: a systematic review and meta-analysis

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  3. Persistent post-traumatic headache attributed to mild traumatic brain injury: Deep phenotyping and treatment patterns

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  4. Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura

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  5. Plasma Glucose Levels Increase During Spontaneous Attacks of Migraine With and Without Aura

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Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Additionally, BKCa channels are downstream molecules in migraine signalling pathways that are activated by several compounds known to provoke migraine, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and glyceryl trinitrate (GTN). Also, there is a high affinity and a close coupling between BKCa channels and ATP-sensitive potassium (KATP) channels, the role of which has recently been established in migraine pathophysiology. These observations raise the question as to whether direct BKCa channel activation can provoke migraine in migraine patients, and whether the BKCa channel could be a potential novel anti-migraine target. Hence, randomized and placebo-controlled clinical studies on BKCa channel openers or blockers in migraine patients are needed.

Original languageEnglish
JournalCNS Drugs
Volume34
Issue number4
Pages (from-to)325-335
Number of pages11
ISSN1172-7047
DOIs
Publication statusPublished - Apr 2020

ID: 59482800