Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E Grier; Anders H Hansen; Christina S Haxvig; Xin Li; Oliver Krigslund; Niels Behrendt; Lars H Engelholm; Fabio Rossi; Bebiana C Sousa; Grant J Harradence; Nicolas Camper; Katrine M Qvortrup

doi:10.1039/d3cc01596c

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E Grier, Anders H Hansen, Christina S Haxvig, Xin Li, Oliver Krigslund, Niels Behrendt, Lars H Engelholm, Fabio Rossi, Bebiana C Sousa, Grant J Harradence, Nicolas Camper, Katrine M Qvortrup^*

^*Corresponding author for this work

The Finsen Laboratory

4 Citations (Scopus)

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

Original language	English
Journal	Chemical Communications
Volume	59
Issue number	47
Pages (from-to)	7240-7242
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/d3cc01596c
Publication status	Published - 8 Jun 2023

Keywords

Animals
Antineoplastic Agents/pharmacology
Ethanol
Humans
Immunoconjugates/pharmacology
Mice

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10.1039/d3cc01596c

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title = "Targeted delivery of alcohol-containing payloads with antibody-drug conjugates",

abstract = "We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.",

keywords = "Animals, Antineoplastic Agents/pharmacology, Ethanol, Humans, Immunoconjugates/pharmacology, Mice",

author = "Grier, \{Katja E\} and Hansen, \{Anders H\} and Haxvig, \{Christina S\} and Xin Li and Oliver Krigslund and Niels Behrendt and Engelholm, \{Lars H\} and Fabio Rossi and Sousa, \{Bebiana C\} and Harradence, \{Grant J\} and Nicolas Camper and Qvortrup, \{Katrine M\}",

year = "2023",

month = jun,

day = "8",

doi = "10.1039/d3cc01596c",

language = "English",

volume = "59",

pages = "7240--7242",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "47",

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TY - JOUR

T1 - Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

AU - Grier, Katja E

AU - Hansen, Anders H

AU - Haxvig, Christina S

AU - Li, Xin

AU - Krigslund, Oliver

AU - Behrendt, Niels

AU - Engelholm, Lars H

AU - Rossi, Fabio

AU - Sousa, Bebiana C

AU - Harradence, Grant J

AU - Camper, Nicolas

AU - Qvortrup, Katrine M

PY - 2023/6/8

Y1 - 2023/6/8

N2 - We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

AB - We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

KW - Animals

KW - Antineoplastic Agents/pharmacology

KW - Ethanol

KW - Humans

KW - Immunoconjugates/pharmacology

KW - Mice

UR - https://www.scopus.com/pages/publications/85161660502

U2 - 10.1039/d3cc01596c

DO - 10.1039/d3cc01596c

M3 - Journal article

C2 - 37222285

SN - 1359-7345

VL - 59

SP - 7240

EP - 7242

JO - Chemical Communications

JF - Chemical Communications

IS - 47

ER -

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Abstract

Keywords

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