Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting

Research output: Contribution to journalReviewpeer-review

  1. The effects of targeted immune-regulatory strategies on tumor-specific T-cell responses in vitro

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. In vitro 4-1BB stimulation promotes expansion of CD8+ tumor-infiltrating lymphocytes from various sarcoma subtypes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The capacity of CD4+ Vγ9Vδ2 T cells to kill cancer cells correlates with co-expression of CD56

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. TAM Receptor Inhibition-Implications for Cancer and the Immune System

    Research output: Contribution to journalReviewpeer-review

  3. Adrenergic Signaling in Immunotherapy of Cancer: Friend or Foe?

    Research output: Contribution to journalReviewpeer-review

  4. Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

    Research output: Contribution to journalReviewpeer-review

View graph of relations

The TAM receptors-TYRO3, AXL, MERTK-are pleiotropically expressed receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) or Growth Arrest-Specific 6 (GAS6) with apoptotic phosphatidylserine activates the TAM receptors. Hence, this receptor family is essential for the efferocytosis of apoptotic material by antigen-presenting cells. In addition, TAM receptors are expressed by virtually all cells of the tumor microenvironment. They are also potent oncogenes, frequently overexpressed in cancer and involved in survival and therapy resistance. Due to their pro-oncogenic and immune-inhibitory traits, TAM receptors have emerged as promising targets for cancer therapy. Recently, TAM receptors have been described to function as costimulatory molecules on human T cells. TAM receptors' ambivalent functions on many different cell types therefore make therapeutic targeting not straight-forward. In this review we summarize our current knowledge of the function of TAM receptors in the tumor microenvironment. We place particular focus on TAM receptors and the recently unraveled role of MERTK in activated T cells and potential consequences for anti-tumor immunity.

Original languageEnglish
JournalCancer immunology, immunotherapy
ISSN0340-7004
DOIs
Publication statusPublished - 29 Oct 2019

ID: 58521903