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The Capital Region of Denmark
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T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
Research output: Contribution to journal › Journal article › Research › peer-review
Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P
| Original language | English |
|---|---|
| Journal | Immunology |
| Volume | 125 |
| Issue number | 2 |
| Pages (from-to) | 161-9 |
| Number of pages | 9 |
| ISSN | 0019-2805 |
| DOIs | |
| Publication status | Published - 1 Oct 2008 |
ID: 31051666