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The Capital Region of Denmark - a part of Copenhagen University Hospital
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T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

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  1. Frequency and immunophenotype of IL10-producing regulatory B cells in optic neuritis

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  2. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

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  3. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

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  4. Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding Mycobacterium tuberculosis peptides

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  1. Thyroid peroxidase antibodies and prospective live birth rate: A cohort study of women with recurrent pregnancy loss

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  2. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  3. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P
Original languageEnglish
JournalImmunology
Volume125
Issue number2
Pages (from-to)161-9
Number of pages9
ISSN0019-2805
DOIs
Publication statusPublished - 1 Oct 2008

ID: 31051666