T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

Chris J Hedegaard, Martin Krakauer, Klaus Bendtzen, Henrik Lund, Finn Sellebjerg, Claus H Nielsen

169 Citations (Scopus)

Abstract

Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P
Original languageEnglish
JournalImmunology
Volume125
Issue number2
Pages (from-to)161-9
Number of pages9
ISSN0019-2805
DOIs
Publication statusPublished - 1 Oct 2008

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