T-cell responses in malaria

L Hviid; P H Jakobsen; Y A Abu-Zeid; T G Theander

doi:10.1111/j.1699-0463.1992.tb00846.x

T-cell responses in malaria

L Hviid, P H Jakobsen, Y A Abu-Zeid, T G Theander

11 Citations (Scopus)

Abstract

Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

Original language	English
Journal	APMIS - Journal of Pathology, Microbiology and Immunology
Volume	100
Issue number	2
Pages (from-to)	95-106
Number of pages	12
ISSN	0903-4641
DOIs	https://doi.org/10.1111/j.1699-0463.1992.tb00846.x
Publication status	Published - Feb 1992
Externally published	Yes

Keywords

Amino Acid Sequence
Animals
Antigens, Protozoan/immunology
Humans
Immunity, Cellular
Malaria/immunology
Malaria, Falciparum/immunology
Molecular Sequence Data
T-Lymphocytes/immunology

Access to Document

10.1111/j.1699-0463.1992.tb00846.x

Cite this

@article{bf4ecfc6bb184f31b91c4439d63cdc21,

title = "T-cell responses in malaria",

abstract = "Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.",

keywords = "Amino Acid Sequence, Animals, Antigens, Protozoan/immunology, Humans, Immunity, Cellular, Malaria/immunology, Malaria, Falciparum/immunology, Molecular Sequence Data, T-Lymphocytes/immunology",

author = "L Hviid and Jakobsen, {P H} and Abu-Zeid, {Y A} and Theander, {T G}",

year = "1992",

month = feb,

doi = "10.1111/j.1699-0463.1992.tb00846.x",

language = "English",

volume = "100",

pages = "95--106",

journal = "APMIS - Journal of Pathology, Microbiology and Immunology",

issn = "0903-4641",

publisher = "Wiley Online",

number = "2",

}

TY - JOUR

T1 - T-cell responses in malaria

AU - Hviid, L

AU - Jakobsen, P H

AU - Abu-Zeid, Y A

AU - Theander, T G

PY - 1992/2

Y1 - 1992/2

N2 - Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

AB - Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, Protozoan/immunology

KW - Humans

KW - Immunity, Cellular

KW - Malaria/immunology

KW - Malaria, Falciparum/immunology

KW - Molecular Sequence Data

KW - T-Lymphocytes/immunology

U2 - 10.1111/j.1699-0463.1992.tb00846.x

DO - 10.1111/j.1699-0463.1992.tb00846.x

M3 - Review

C2 - 1554496

SN - 0903-4641

VL - 100

SP - 95

EP - 106

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

IS - 2

ER -

T-cell responses in malaria

Abstract

Keywords

Access to Document

Fingerprint

Cite this