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T 2 mapping of cerebrospinal fluid: 3 T versus 7 T

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  • Jolanda M Spijkerman
  • Esben T Petersen
  • Jeroen Hendrikse
  • Peter Luijten
  • Jaco J M Zwanenburg
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OBJECT: Cerebrospinal fluid (CSF) T 2 mapping can potentially be used to investigate CSF composition. A previously proposed CSF T 2-mapping method reported a T 2 difference between peripheral and ventricular CSF, and suggested that this reflected different CSF compositions. We studied the performance of this method at 7 T and evaluated the influence of partial volume and B 1 and B 0 inhomogeneity.

MATERIALS AND METHODS: T 2-preparation-based CSF T 2-mapping was performed in seven healthy volunteers at 7 and 3 T, and was compared with a single echo spin-echo sequence with various echo times. The influence of partial volume was assessed by our analyzing the longest echo times only. B 1 and B 0 maps were acquired. B 1 and B 0 dependency of the sequences was tested with a phantom.

RESULTS: T 2,CSF was shorter at 7 T compared with 3 T. At 3 T, but not at 7 T, peripheral T 2,CSF was significantly shorter than ventricular T 2,CSF. Partial volume contributed to this T 2 difference, but could not fully explain it. B 1 and B 0 inhomogeneity had only a very limited effect. T 2,CSF did not depend on the voxel size, probably because of the used method to select of the regions of interest.

CONCLUSION: CSF T 2 mapping is feasible at 7 T. The shorter peripheral T 2,CSF is likely a combined effect of partial volume and CSF composition.

Original languageEnglish
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume31
Issue number3
Pages (from-to)415-424
ISSN0968-5243
DOIs
Publication statusPublished - 1 Jun 2018

    Research areas

  • Journal Article

ID: 52054812