Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study

Research output: Contribution to journalJournal articlepeer-review

  1. Neurocognitive Development in Children at Familial High Risk of Schizophrenia or Bipolar Disorder

    Research output: Contribution to journalJournal articlepeer-review

  2. Rating the importance of outcomes from diabetes trials. A survey of patients’ and doctors’ opinions

    Research output: Contribution to journalJournal articlepeer-review

  3. Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.

Original languageEnglish
JournalPsychiatry Research
Volume241
Pages (from-to)201-206
Number of pages6
ISSN0165-1781
DOIs
Publication statusPublished - 30 Apr 2016

ID: 46462093