Systemic Lupus Erythematosus Risk: The Role of Environmental Factors

Jia Li Liu; Jennifer M.P. Woo; Christine G. Parks; Karen H. Costenbader; Søren Jacobsen; Sasha Bernatsky

doi:10.1016/j.rdc.2022.06.005

Systemic Lupus Erythematosus Risk: The Role of Environmental Factors

Jia Li Liu, Jennifer M.P. Woo, Christine G. Parks, Karen H. Costenbader, Søren Jacobsen, Sasha Bernatsky^*

^*Corresponding author for this work

Department for Rheumatology and Spine Diseases

17 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.

Original language	English
Journal	Rheumatic Disease Clinics of North America
Volume	48
Issue number	4
Pages (from-to)	827-843
Number of pages	17
ISSN	0889-857X
DOIs	https://doi.org/10.1016/j.rdc.2022.06.005
Publication status	Published - 2022

Keywords

Environmental triggers
Infections
Microbiome
Pollution
Smoking
Systemic lupus erythematosus

Access to Document

10.1016/j.rdc.2022.06.005

Cite this

@article{d075720a1db944109df15685bc25fd5e,

title = "Systemic Lupus Erythematosus Risk: The Role of Environmental Factors",

abstract = "Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the {"}multi-hit{"} hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.",

keywords = "Environmental triggers, Infections, Microbiome, Pollution, Smoking, Systemic lupus erythematosus",

author = "Liu, \{Jia Li\} and Woo, \{Jennifer M.P.\} and Parks, \{Christine G.\} and Costenbader, \{Karen H.\} and S{\o}ren Jacobsen and Sasha Bernatsky",

note = "Funding Information: The authors have nothing to disclose.",

year = "2022",

doi = "10.1016/j.rdc.2022.06.005",

language = "English",

volume = "48",

pages = "827--843",

journal = "Rheumatic Disease Clinics of North America",

issn = "0889-857X",

publisher = "W.B. Saunders",

number = "4",

}

TY - JOUR

T1 - Systemic Lupus Erythematosus Risk

T2 - The Role of Environmental Factors

AU - Liu, Jia Li

AU - Woo, Jennifer M.P.

AU - Parks, Christine G.

AU - Costenbader, Karen H.

AU - Jacobsen, Søren

AU - Bernatsky, Sasha

N1 - Funding Information: The authors have nothing to disclose.

PY - 2022

Y1 - 2022

N2 - Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.

AB - Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.

KW - Environmental triggers

KW - Infections

KW - Microbiome

KW - Pollution

KW - Smoking

KW - Systemic lupus erythematosus

UR - https://www.scopus.com/pages/publications/85139193519

U2 - 10.1016/j.rdc.2022.06.005

DO - 10.1016/j.rdc.2022.06.005

M3 - Review

C2 - 36332998

AN - SCOPUS:85139193519

SN - 0889-857X

VL - 48

SP - 827

EP - 843

JO - Rheumatic Disease Clinics of North America

JF - Rheumatic Disease Clinics of North America

IS - 4

ER -

Systemic Lupus Erythematosus Risk: The Role of Environmental Factors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this