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Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study

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  1. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

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  2. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

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  3. HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

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  1. Development and validation of a multiple-choice questionnaire-based theoretical test in direct ophthalmoscopy

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  2. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  3. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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  4. Functional neuroimaging of recovery from motor conversion disorder: A case report

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Age-related macular degeneration (AMD) is a degenerative disease of the retina and a leading cause of irreversible vision loss. We investigated the systemic differences in the frequency of T helper (Th) 1 and Th17 cells in patients with non-exudative and exudative AMD and compared to age-matched controls. Flow cytometry was used to determine the systemic frequency of Th1 (CD4+CXCR3+IL12RB2+) and Th17 (CD4+CCR6+IL23R+) cells, and percentage of CD4+ T-cells expressing CXCR3, IL12RB2, CCR6, IL23R, and co-expressing CXCR3 and CCR6. The frequency of Th1 cells and CXCR3+ CD4+ T-cells was lower in patients with exudative AMD. A significant age-dependent decrement in Th1 was observed in controls, but not in non-exudative or exudative AMD. This may be related to the CXCR3+ CD4+ T-cells, which showed similar pattern in controls, but not in non-exudative or exudative AMD. No significant group differences were observed for the frequency of Th17 cells. Correlation networks found several differences between controls and AMD. These data suggests the involvement of the adaptive immune system in AMD and supports the notion of AMD as a systemic disease. Our observations warrant further investigation into the role of the adaptive immune system in the pathogenesis of AMD.

Original languageEnglish
JournalScientific Reports
Volume7
Issue number1
Pages (from-to)605
ISSN2045-2322
DOIs
Publication statusPublished - 4 Apr 2017

    Research areas

  • Journal Article

ID: 52217691