Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Synchronous and metachronous liver metastases in patients with colorectal cancer

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Temporal trends in length of stay and readmissions after fast-track hip and knee arthroplasty

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hydrochloric acid prolongs the lifetime of central venous catheters in haematologic patients with bacteraemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Successful paediatric renography does not require sedation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Indwelling urinary catheterisation may increase risk of complications in hip and knee arthroplasty

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The clinical use of hyperbaric oxygen in the treatment of Danish patients with diabetic foot ulcers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Response to the Comment on "Should We Have a Little More Patience With the Conventional 2-Stage Hepatectomy?"

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Nonalcoholic fatty liver disease is an increasing indication for liver transplantation in the Nordic countries

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Continuous vital sign monitoring after major abdominal surgery-Quantification of micro events

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Liver metastases are the most common complication to colorectal cancer, and the presence of metastatic disease severely impacts the overall prognosis of the disease. Since the diagnostic work-up of metastasised colorectal cancer has undergone tremendous changes in past decades, an impact on the incidence of metastatic disease is anticipated. The aim of this study was to evaluate the incidence and prognosis of liver metastasis in patients with colorectal cancer.

METHODS: From 1 January 2005 to 31 December 2011, all patients with a primary diagnosis of colorectal cancer were identified. Data on metastatic dissemination to the liver were collected from medical charts. Patients were followed until death or the end of the study period (31 December 2016).

RESULTS: Among the total study population of 1,672 patients, 23.6% of patients were diagnosed with liver metastases. The incidence of synchronous and metachronous metastases was 16% and 7.7%, respectively. Patients with synchronous and metachronous metastases had a median survival of ten (95% confidence interval (CI): 7.5-12.5) and 43 (95% CI: 35.8-50.2) months, respectively, compared with a median survival of 86 (95% CI: 73.5-98.5) months for patients without liver metastases.

CONCLUSIONS: The incidence of synchronous metastases has remained high despite improved diagnostic technology. Patient survival remains significantly lower when metastatic disease is present, even though treatment options for liver metastases have improved.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

Original languageEnglish
JournalDanish Medical Journal
Volume65
Issue number12
Pages (from-to)A5524
ISSN1603-9629
Publication statusPublished - Dec 2018

ID: 56479968