Switching from high doses of pure μ-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study

Lena Lundorff; Per Sjøgren; Ole Bo Hansen; Torsten Jonsson; Per Rotbøll Nielsen; Lona Christrup

doi:10.5055/jom.2013.0166

Switching from high doses of pure μ-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study

Lena Lundorff, Per Sjøgren, Ole Bo Hansen, Torsten Jonsson, Per Rotbøll Nielsen, Lona Christrup

11 Citations (Scopus)

Abstract

Several myths on buprenorphine's pharmacology exist: possible analgesic ceiling effect, feasibility of combination with other opioid agonists, and the reversibility of side effects. Aim to evaluate: 1) if cancer patients receiving high doses of pure agonists could obtain adequate pain relief after switching to transdermal (TD) buprenorphine and 2) whether the numbers of breakthrough pain episodes after switching increased and whether they could be treated with the same doses of pure agonist as before switching.

Original language	English
Journal	Journal of Opioid Management
Volume	9
Issue number	4
Pages (from-to)	255-62
Number of pages	8
ISSN	1551-7489
DOIs	https://doi.org/10.5055/jom.2013.0166
Publication status	Published - 2013

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10.5055/jom.2013.0166

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AU - Lundorff, Lena

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AU - Hansen, Ole Bo

AU - Jonsson, Torsten

AU - Nielsen, Per Rotbøll

AU - Christrup, Lona

PY - 2013

Y1 - 2013

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AB - Several myths on buprenorphine's pharmacology exist: possible analgesic ceiling effect, feasibility of combination with other opioid agonists, and the reversibility of side effects. Aim to evaluate: 1) if cancer patients receiving high doses of pure agonists could obtain adequate pain relief after switching to transdermal (TD) buprenorphine and 2) whether the numbers of breakthrough pain episodes after switching increased and whether they could be treated with the same doses of pure agonist as before switching.

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U2 - 10.5055/jom.2013.0166

DO - 10.5055/jom.2013.0166

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Switching from high doses of pure μ-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study

Abstract

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