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Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder-A Nationwide Observational Cohort Study

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@article{6e0c6f3f1dc74218bb78ccb6bede3481,
title = "Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder-A Nationwide Observational Cohort Study",
abstract = "BACKGROUND: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children.METHODS: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners' Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers.RESULTS: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy.CONCLUSIONS: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.",
author = "Burton, {Birgitte Klee} and Signe Vangkilde and Anders Petersen and Skovgaard, {Lene Theil} and Jepsen, {Jens Richardt} and Nicoline Hemager and Christiani, {Camilla Jerlang} and Spang, {Katrine Soeborg} and Ditte Ellersgaard and Aja Greve and Ditte Gantriis and Heike Eichele and Ole Mors and Merete Nordentoft and Thorup, {Anne Amalie Elgaard} and Plessen, {Kerstin Jessica}",
note = "Copyright {\circledC} 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = "8",
doi = "10.1016/j.bpsc.2018.04.012",
language = "English",
volume = "3",
pages = "704--712",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Elsevier BV",
number = "8",

}

RIS

TY - JOUR

T1 - Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder-A Nationwide Observational Cohort Study

AU - Burton, Birgitte Klee

AU - Vangkilde, Signe

AU - Petersen, Anders

AU - Skovgaard, Lene Theil

AU - Jepsen, Jens Richardt

AU - Hemager, Nicoline

AU - Christiani, Camilla Jerlang

AU - Spang, Katrine Soeborg

AU - Ellersgaard, Ditte

AU - Greve, Aja

AU - Gantriis, Ditte

AU - Eichele, Heike

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Thorup, Anne Amalie Elgaard

AU - Plessen, Kerstin Jessica

N1 - Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - BACKGROUND: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children.METHODS: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners' Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers.RESULTS: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy.CONCLUSIONS: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.

AB - BACKGROUND: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children.METHODS: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners' Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers.RESULTS: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy.CONCLUSIONS: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.

U2 - 10.1016/j.bpsc.2018.04.012

DO - 10.1016/j.bpsc.2018.04.012

M3 - Journal article

VL - 3

SP - 704

EP - 712

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

SN - 2451-9022

IS - 8

ER -

ID: 54707820