Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Susceptibility to Lower Respiratory Infections in Childhood is Associated with Perturbation of the Cytokine Response to Pathogenic Airway Bacteria

Research output: Contribution to journalJournal articleResearchpeer-review

  1. LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pediatric Candidemia Epidemiology and Morbidities: A Nationwide Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Streptococcal Infections and Exacerbations in PANDAS: A Systematic Review and Meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Allergen Specificity in Specific IgE Cutoff

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Allergitest hos børn: flere spørgsmål end svar

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Neonatal colonization of the airways with respiratory pathogens is associated with increased risk of lower respiratory infections (LRI) in early childhood. Therefore, we hypothesized that children developing LRI have an aberrant immune response to pathogenic bacteria in infancy.

OBJECTIVE: To characterize in vitro the early life systemic immune response to pathogenic bacteria and study the possible association with incidence of LRI during the first 3 years of life.

METHODS: The Copenhagen Prospective Study on Asthma in Childhood2000 (COPSAC2000) is a clinical birth cohort study of 411 children born of mothers with asthma. LRI incidence was prospectively captured from 6-monthly planned visits and visits at acute respiratory episodes. The in vitro systemic immune response to H. influenzae, M. catarrhalis and S. pneumoniae was characterized by the production of TNF-α, IFN-γ, IL-2, IL-5, IL-10, IL-13, and IL-17 in peripheral blood mononuclear cells isolated at age 6 months from 291 infants. Data were analyzed by Poisson regression against incidence of LRI in infancy.

RESULTS: A multivariable model including all cytokine responses from the three different bacterial stimulations significantly identified children at risk of LRI (p=0.006). The immune response pattern associated with LRI was characterized by perturbed production of several cytokines rather than production of one specific cytokine, and was independent of concurrent asthma. TNF-α and IL-5 were key drivers but did not explain the entire variation in LRI susceptibility.

CONCLUSIONS: Children at risk of future LRI present a pertubed systemic immune response upon exposure to common airway pathogens in early life.

Original languageEnglish
JournalThe Pediatric infectious disease journal
Volume35
Issue number5
Pages (from-to)561-566
Number of pages6
ISSN0891-3668
DOIs
Publication statusPublished - 23 Feb 2016

ID: 46449633