Susceptibility mutations for ischemic heart disease

B G Nordestgaard; A Tybjaerg-Hansen

doi:10.1007/s11883-999-0006-x

Susceptibility mutations for ischemic heart disease

7 Citations (Scopus)

Abstract

In The Copenhagen City Heart Study, apolipoprotein B Arg3500Gln and Arg3531Cys increased plasma cholesterol 41% and 0%, lipoprotein lipase Gly188Glu, Asn291Ser, and Asp9Asn increased plasma triglycerides 42%, 13% (women only), and 13% (men only), and angiotensin converting enzyme DD increased plasma ACE activity 57%. Risk of ischemic heart disease for these mutations was sevenfold, unchanged, fivefold, twofold (women only), twofold (men only), and unchanged, respectively, compared with threefold for diabetes mellitus. The fraction of ischemic heart disease in the population at large attributed to these mutations was 0.5%, 0%, 0.3%, 5% (women only), 3% (men only), and 0%, respectively, compared with 7% for diabetes mellitus.

Original language	English
Journal	Current Atherosclerosis Reports
Volume	1
Issue number	2
Pages (from-to)	108-14
Number of pages	7
ISSN	1523-3804
DOIs	https://doi.org/10.1007/s11883-999-0006-x
Publication status	Published - Sept 1999
Externally published	Yes

Keywords

Apolipoproteins B/genetics
Cholesterol/blood
Coronary Disease/blood
Female
Genetic Predisposition to Disease
Humans
Lipoprotein Lipase/genetics
Male
Mutation
Peptidyl-Dipeptidase A/blood
Triglycerides/blood

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10.1007/s11883-999-0006-x

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title = "Susceptibility mutations for ischemic heart disease",

abstract = "In The Copenhagen City Heart Study, apolipoprotein B Arg3500Gln and Arg3531Cys increased plasma cholesterol 41\% and 0\%, lipoprotein lipase Gly188Glu, Asn291Ser, and Asp9Asn increased plasma triglycerides 42\%, 13\% (women only), and 13\% (men only), and angiotensin converting enzyme DD increased plasma ACE activity 57\%. Risk of ischemic heart disease for these mutations was sevenfold, unchanged, fivefold, twofold (women only), twofold (men only), and unchanged, respectively, compared with threefold for diabetes mellitus. The fraction of ischemic heart disease in the population at large attributed to these mutations was 0.5\%, 0\%, 0.3\%, 5\% (women only), 3\% (men only), and 0\%, respectively, compared with 7\% for diabetes mellitus.",

keywords = "Apolipoproteins B/genetics, Cholesterol/blood, Coronary Disease/blood, Female, Genetic Predisposition to Disease, Humans, Lipoprotein Lipase/genetics, Male, Mutation, Peptidyl-Dipeptidase A/blood, Triglycerides/blood",

author = "Nordestgaard, \{B G\} and A Tybjaerg-Hansen",

year = "1999",

month = sep,

doi = "10.1007/s11883-999-0006-x",

language = "English",

volume = "1",

pages = "108--14",

journal = "Current Atherosclerosis Reports",

issn = "1523-3804",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Susceptibility mutations for ischemic heart disease

AU - Nordestgaard, B G

AU - Tybjaerg-Hansen, A

PY - 1999/9

Y1 - 1999/9

N2 - In The Copenhagen City Heart Study, apolipoprotein B Arg3500Gln and Arg3531Cys increased plasma cholesterol 41% and 0%, lipoprotein lipase Gly188Glu, Asn291Ser, and Asp9Asn increased plasma triglycerides 42%, 13% (women only), and 13% (men only), and angiotensin converting enzyme DD increased plasma ACE activity 57%. Risk of ischemic heart disease for these mutations was sevenfold, unchanged, fivefold, twofold (women only), twofold (men only), and unchanged, respectively, compared with threefold for diabetes mellitus. The fraction of ischemic heart disease in the population at large attributed to these mutations was 0.5%, 0%, 0.3%, 5% (women only), 3% (men only), and 0%, respectively, compared with 7% for diabetes mellitus.

AB - In The Copenhagen City Heart Study, apolipoprotein B Arg3500Gln and Arg3531Cys increased plasma cholesterol 41% and 0%, lipoprotein lipase Gly188Glu, Asn291Ser, and Asp9Asn increased plasma triglycerides 42%, 13% (women only), and 13% (men only), and angiotensin converting enzyme DD increased plasma ACE activity 57%. Risk of ischemic heart disease for these mutations was sevenfold, unchanged, fivefold, twofold (women only), twofold (men only), and unchanged, respectively, compared with threefold for diabetes mellitus. The fraction of ischemic heart disease in the population at large attributed to these mutations was 0.5%, 0%, 0.3%, 5% (women only), 3% (men only), and 0%, respectively, compared with 7% for diabetes mellitus.

KW - Apolipoproteins B/genetics

KW - Cholesterol/blood

KW - Coronary Disease/blood

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Lipoprotein Lipase/genetics

KW - Male

KW - Mutation

KW - Peptidyl-Dipeptidase A/blood

KW - Triglycerides/blood

UR - https://www.scopus.com/pages/publications/0033187817

U2 - 10.1007/s11883-999-0006-x

DO - 10.1007/s11883-999-0006-x

M3 - Review

C2 - 11122699

SN - 1523-3804

VL - 1

SP - 108

EP - 114

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

IS - 2

ER -

Susceptibility mutations for ischemic heart disease

Abstract

Keywords

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