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Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

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  1. Clinical Examination for the Prediction of Mortality in the Critically Ill: The Simple Intensive Care Studies-I

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Luxury Perfusion in Patients With Sepsis?

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  1. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

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  2. Thrombocytopenia in intensive care unit patients: A scoping review

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Waleed Alhazzani
  • Morten Hylander Møller
  • Yaseen M Arabi
  • Mark Loeb
  • Michelle Ng Gong
  • Eddy Fan
  • Simon Oczkowski
  • Mitchell M Levy
  • Lennie Derde
  • Amy Dzierba
  • Bin Du
  • Michael Aboodi
  • Hannah Wunsch
  • Maurizio Cecconi
  • Younsuck Koh
  • Daniel S Chertow
  • Kathryn Maitland
  • Fayez Alshamsi
  • Emilie Belley-Cote
  • Massimiliano Greco
  • Matthew Laundy
  • Jill S Morgan
  • Jozef Kesecioglu
  • Allison McGeer
  • Leonard Mermel
  • Manoj J Mammen
  • Paul E Alexander
  • Amy Arrington
  • John E Centofanti
  • Giuseppe Citerio
  • Bandar Baw
  • Ziad A Memish
  • Naomi Hammond
  • Frederick G Hayden
  • Laura Evans
  • Andrew Rhodes
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BACKGROUND: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

METHODS: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

RESULTS: The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which four are best practice statements, nine are strong recommendations, and 35 are weak recommendations. No recommendation was provided for six questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy.

CONCLUSION: The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.

Original languageEnglish
JournalCritical Care Medicine
Volume48
Issue number6
Pages (from-to)e440-e469
ISSN0090-3493
DOIs
Publication statusPublished - Jun 2020

    Research areas

  • Betacoronavirus, COVID-19, Coronavirus Infections/therapy, Critical Illness, Diagnostic Techniques and Procedures/standards, Humans, Infection Control/methods, Intensive Care Units/organization & administration, Pandemics, Pneumonia, Viral/therapy, Practice Guidelines as Topic/standards, Respiration, Artificial/methods, SARS-CoV-2, Shock/therapy

ID: 61903573