Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

Ann Olsson; Liacine Bouaoun; Anssi Auvinen; Maria Feychting; Christoffer Johansen; Tiit Mathiesen; Beatrice Melin; Anna Lahkola; Suvi Larjavaara; Anne-Sophie Villegier; Graham Byrnes; Isabelle Deltour; Joachim Schüz

doi:10.1007/s11060-018-03019-5

Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

Ann Olsson, Liacine Bouaoun, Anssi Auvinen, Maria Feychting, Christoffer Johansen, Tiit Mathiesen, Beatrice Melin, Anna Lahkola, Suvi Larjavaara, Anne-Sophie Villegier, Graham Byrnes, Isabelle Deltour, Joachim Schüz

9 Citations (Scopus)

Abstract

PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients.

METHODS: Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status.

RESULTS: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas.

CONCLUSIONS: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.

Original language	English
Journal	Journal of Neuro-Oncology
Volume	141
Issue number	1
Pages (from-to)	139-149
Number of pages	11
ISSN	0167-594X
DOIs	https://doi.org/10.1007/s11060-018-03019-5
Publication status	Published - Jan 2019

Keywords

Case–control studies
Glioma
Mobile phones
Radiofrequency electromagnetic fields
Survival
Humans
Middle Aged
Radio Waves/adverse effects
Male
Cell Phone Use
Case-Control Studies
Finland/epidemiology
Young Adult
Denmark/epidemiology
Glioma/mortality
Adolescent
Adult
Female
Aged
Brain Neoplasms/mortality
Sweden/epidemiology

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10.1007/s11060-018-03019-5

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title = "Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden",

abstract = "PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients.METHODS: Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status.RESULTS: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas.CONCLUSIONS: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.",

keywords = "Case–control studies, Glioma, Mobile phones, Radiofrequency electromagnetic fields, Survival, Humans, Middle Aged, Radio Waves/adverse effects, Male, Cell Phone Use, Case-Control Studies, Finland/epidemiology, Young Adult, Denmark/epidemiology, Glioma/mortality, Adolescent, Adult, Female, Aged, Brain Neoplasms/mortality, Sweden/epidemiology",

author = "Ann Olsson and Liacine Bouaoun and Anssi Auvinen and Maria Feychting and Christoffer Johansen and Tiit Mathiesen and Beatrice Melin and Anna Lahkola and Suvi Larjavaara and Anne-Sophie Villegier and Graham Byrnes and Isabelle Deltour and Joachim Sch{\"u}z",

year = "2019",

month = jan,

doi = "10.1007/s11060-018-03019-5",

language = "English",

volume = "141",

pages = "139--149",

journal = "Journal of Neuro-Oncology",

issn = "0167-594X",

publisher = "Springer New York LLC",

number = "1",

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TY - JOUR

T1 - Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

AU - Olsson, Ann

AU - Bouaoun, Liacine

AU - Auvinen, Anssi

AU - Feychting, Maria

AU - Johansen, Christoffer

AU - Mathiesen, Tiit

AU - Melin, Beatrice

AU - Lahkola, Anna

AU - Larjavaara, Suvi

AU - Villegier, Anne-Sophie

AU - Byrnes, Graham

AU - Deltour, Isabelle

AU - Schüz, Joachim

PY - 2019/1

Y1 - 2019/1

N2 - PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients.METHODS: Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status.RESULTS: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas.CONCLUSIONS: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.

AB - PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients.METHODS: Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status.RESULTS: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas.CONCLUSIONS: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.

KW - Case–control studies

KW - Glioma

KW - Mobile phones

KW - Radiofrequency electromagnetic fields

KW - Survival

KW - Humans

KW - Middle Aged

KW - Radio Waves/adverse effects

KW - Male

KW - Cell Phone Use

KW - Case-Control Studies

KW - Finland/epidemiology

KW - Young Adult

KW - Denmark/epidemiology

KW - Glioma/mortality

KW - Adolescent

KW - Adult

KW - Female

KW - Aged

KW - Brain Neoplasms/mortality

KW - Sweden/epidemiology

U2 - 10.1007/s11060-018-03019-5

DO - 10.1007/s11060-018-03019-5

M3 - Journal article

C2 - 30421160

SN - 0167-594X

VL - 141

SP - 139

EP - 149

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 1

ER -

Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden

Abstract

Keywords

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