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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Survival after bone metastasis by primary cancer type: a Danish population-based cohort study

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  1. Football training over 5 years is associated with preserved femoral bone mineral density in men with prostate cancer

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  2. Frozen shoulder and risk of cancer: a population-based cohort study

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  3. Muscle satellite cell content and mRNA signaling in germ cell cancer patients - effects of chemotherapy and resistance training

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  • Elisabeth Svensson
  • Christian F Christiansen
  • Sinna P Ulrichsen
  • Mikael R Rørth
  • Henrik T Sørensen
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OBJECTIVE: In the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases.

METHODS: We included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first. We computed 1-year, 3-year and 5-year survival (%) and the corresponding 95% CIs stratified on primary cancer type. Comparing patients with bone metastasis only and patients with other synchronous metastases, we estimated crude and adjusted HRs and corresponding 95% CI for mortality.

RESULTS: We included 17 251 patients with bone metastasis. The most common primary cancer types with bone metastasis were prostate (34%), breast (22%) and lung (20%). One-year survival after bone metastasis diagnosis was lowest in patients with lung cancer (10%, 95% CI 9% to 11%) and highest in patients with breast cancer (51%, 50% to 53%). At 5 years of follow-up, only patients with breast cancer had over 10% survival (13%, 11% to 14%). The risk of mortality was increased for the majority of cancer types among patients with bone and synchronous metastases compared with bone only (adjusted relative risk 1.29-1.57), except for cervix, ovarian and bladder cancer.

CONCLUSIONS: While patients with bone metastases after most primary cancers have poor survival, one of ten patients with bone metastasis from breast cancer survived 5 years.

Original languageEnglish
JournalBMJ Paediatrics Open
Volume7
Issue number9
Pages (from-to)e016022
ISSN2044-6055
DOIs
Publication statusPublished - 11 Sep 2017

    Research areas

  • Journal Article

ID: 52151162