Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M Hammerum; Ulrik S Justesen; Mette Pinholt; Louise Roer; Hülya Kaya; Peder Worning; Sanne Nygaard; Michael Kemp; Marianne Engell Clausen; Karen Leth Nielsen; Jurgita Samulioniené; Mona Kjærsgaard; Claus Østergaard; John Coia; Turid Snekloth Søndergaard; Shahin Gaini; Kristian Schønning; Henrik Westh; Henrik Hasman; Barbara Juliane Holzknecht

doi:10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M Hammerum, Ulrik S Justesen, Mette Pinholt, Louise Roer, Hülya Kaya, Peder Worning, Sanne Nygaard, Michael Kemp, Marianne Engell Clausen, Karen Leth Nielsen, Jurgita Samulioniené, Mona Kjærsgaard, Claus Østergaard, John Coia, Turid Snekloth Søndergaard, Shahin Gaini, Kristian Schønning, Henrik Westh, Henrik Hasman, Barbara Juliane Holzknecht

56 Citations (Scopus)

Abstract

We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type.

Original language	English
Journal	Eurosurveillance
Volume	24
Issue number	34
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503
Publication status	Published - Aug 2019

Keywords

Enterococci
MLST
vanA
vanB
VRE
VVE

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10.2807/1560-7917.ES.2019.24.34.1900503

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Hammerum, A. M., Justesen, U. S., Pinholt, M., Roer, L., Kaya, H., Worning, P., Nygaard, S., Kemp, M., Clausen, M. E., Nielsen, K. L., Samulioniené, J., Kjærsgaard, M., Østergaard, C., Coia, J., Søndergaard, T. S., Gaini, S., Schønning, K., Westh, H., Hasman, H., & Holzknecht, B. J. (2019). Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. Eurosurveillance, 24(34). https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. / Hammerum, Anette M; Justesen, Ulrik S; Pinholt, Mette et al.
In: Eurosurveillance, Vol. 24, No. 34, 08.2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Hammerum, AM, Justesen, US, Pinholt, M, Roer, L, Kaya, H, Worning, P, Nygaard, S, Kemp, M, Clausen, ME, Nielsen, KL, Samulioniené, J, Kjærsgaard, M, Østergaard, C, Coia, J, Søndergaard, TS, Gaini, S, Schønning, K , Westh, H, Hasman, H & Holzknecht, BJ 2019, 'Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019', Eurosurveillance, vol. 24, no. 34. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

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title = "Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019",

abstract = "We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44\% belonged to this type.",

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author = "Hammerum, \{Anette M\} and Justesen, \{Ulrik S\} and Mette Pinholt and Louise Roer and H{\"u}lya Kaya and Peder Worning and Sanne Nygaard and Michael Kemp and Clausen, \{Marianne Engell\} and Nielsen, \{Karen Leth\} and Jurgita Samulionien{\'e} and Mona Kj{\ae}rsgaard and Claus {\O}stergaard and John Coia and S{\o}ndergaard, \{Turid Snekloth\} and Shahin Gaini and Kristian Sch{\o}nning and Henrik Westh and Henrik Hasman and Holzknecht, \{Barbara Juliane\}",

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doi = "10.2807/1560-7917.ES.2019.24.34.1900503",

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AU - Justesen, Ulrik S

AU - Pinholt, Mette

AU - Roer, Louise

AU - Kaya, Hülya

AU - Worning, Peder

AU - Nygaard, Sanne

AU - Kemp, Michael

AU - Clausen, Marianne Engell

AU - Nielsen, Karen Leth

AU - Samulioniené, Jurgita

AU - Kjærsgaard, Mona

AU - Østergaard, Claus

AU - Coia, John

AU - Søndergaard, Turid Snekloth

AU - Gaini, Shahin

AU - Schønning, Kristian

AU - Westh, Henrik

AU - Hasman, Henrik

AU - Holzknecht, Barbara Juliane

PY - 2019/8

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AB - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type.

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KW - MLST

KW - vanA

KW - vanB

KW - VRE

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Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Abstract

Keywords

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