Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Perfluorocarbon as an adjuvant for tumor anti-angiogenic therapy: Relevance to hypoxia and HIF-1

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Involvement of steatosis-induced glucagon resistance in hyperglucagonaemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. insulin plays a permissive role for the vasoactive effect of GIP regulating adipose tissue metabolism in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Umbilical cord blood-derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum?

    Research output: Contribution to journalEditorialResearchpeer-review

  4. Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Biological and Clinical Rationale for Androgen Priming in Ovarian Stimulation

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Toxic insult to the gonads by chemotherapy or radiotherapy can lead to permanent infertility. It's an important health concern because each year more than 4000 male patients are at risk of azoospermia in the United States due to gonadotoxicity of the regimens used. There are also several benign/genetic diseases whose natural course can result in infertility without gonadotoxic therapy. Considering the fact that most of these people are cured and survive with the advent of modern medicine, infertility is related to serious psychological and relationship implications and parenthood is a significant issue for those patients. Semen cryopreservation option is available for postpubertal adolescent and adult men, while children do not have this storing option since they do not have mature spermatozoa. However, their testes contain spermatogonial stem cells (SSCs), which are initiators of spermatogenesis. Promising findings in animal studies and human cell lines have encouraged scientists that SSCs may be hope for restoring fertility option of patients who cannot produce functional sperm and who have no other choice to preserve their future fertility. For this reason, several centers around the world already began to collect and cryopreserve testicular tissue or cells with anticipation that SSC-based therapies will be available in the near future; however, an optimal transplantation design in humans is yet to be developed. Here we propose an allogeneic testicular stem cell transplantation with an encapsulation device to restore fertility in patients with infertility. We endeavor to discuss the reliability of this method with the current literature and bring the evidence on its feasibility.

Original languageEnglish
Article number109634
JournalMedical Hypotheses
Volume139
Pages (from-to)109634
ISSN0306-9877
DOIs
Publication statusPublished - Jun 2020

ID: 61255377