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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

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  1. Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

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  2. Electronic applications for the CFQ-R scoring

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  3. Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

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  4. High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study

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  1. Prognosis of COPD depends on severity of exacerbation history: A population-based analysis

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  2. Automated oxygen control with O2matic® during admission with exacerbation of COPD

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  3. Validation of lung density indices by cardiac CT for quantification of lung emphysema

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  4. Airflow limitation in people living with HIV and matched uninfected controls

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  5. Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD

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Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease, their hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.

Original languageEnglish
JournalRespiratory Research
Volume15
Issue number1
Pages (from-to)147
ISSN1465-9921
DOIs
Publication statusPublished - 25 Nov 2014

ID: 45000119