Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Supraclavicular recurrence after early breast cancer: a curable condition?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Screening mammography: benefit of double reading by breast density

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mortality after contralateral breast cancer in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. In-hospital metabolite changes in infective endocarditis-a longitudinal 1H NMR-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Collagen density regulates the activity of tumor-infiltrating T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cerebral oximetry during preoperative resuscitation in elderly patients with hip fracture: a prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
The prognosis of ipsilateral supraclavicular lymph node recurrence after early breast cancer appears to be worse than for other loco-regional recurrences, but better than for distant metastases. The purpose of the present study was to investigate the relationship between different types of salvage treatment and primary patient characteristics, treatment response, and survival after supraclavicular recurrence (SR) in a large patient population. From the Danish Breast Cancer Cooperative Group treatment database 1977-2003, 305 patients were identified with SR without distant disease as site of first recurrence. Salvage treatment types as well as other factors were related to response and survival. The median follow-up time for progression after SR was 25 months. Complete remission was 76% among patients receiving excision surgery, 67% with combined loco-regional and systemic therapy, and 48% with systemic therapy alone. Median progression-free survival (PFS) and overall survival was 18 and 29 months, respectively. The 5-year PFS probability was 15%. In univariate analysis, combination salvage therapy, negative nodal status and low malignancy grade were related to longer PFS. In multivariate analysis, salvage therapy and malignancy grade remained independent factors for survival. In conclusion, the prognosis of SR is generally poor. However, it appears to be a curable condition. An independent marker of improved outcome is local and systemic combination salvage treatment, which can be considered.
Original languageEnglish
JournalBreast Cancer Research and Treatment
Volume125
Issue number3
Pages (from-to)815-22
Number of pages8
ISSN0167-6806
DOIs
Publication statusPublished - 1 Feb 2011

ID: 32237859