TY - JOUR
T1 - Supplementation with fish oil in pregnancy reduces gastroenteritis in early childhood
AU - Horner, David
AU - Hjelmsø, Mathis Hjort
AU - Thorsen, Jonathan
AU - Rasmussen, Morten
AU - Eliasen, Anders
AU - Vinding, Rebecca Kofod
AU - Schoos, Ann-Marie Malby
AU - Brustad, Nicklas
AU - Sunde, Rikke Bjersand
AU - Bønnelykke, Klaus
AU - Chawes, Bo L
AU - Stokholm, Jakob
AU - Bisgaard, Hans
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - BACKGROUND: We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life.METHODS: This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life.RESULTS: A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown.CONCLUSIONS: Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.CLINICAL TRIALS REGISTRATION: NCT00798226.
AB - BACKGROUND: We hypothesized that insufficient intake of fish oil-derived omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy is a contributing factor to gastroenteritis in early childhood. We examined the effect of n-3 LCPUFA supplementation on gastroenteritis symptoms in the offspring's first 3 years of life.METHODS: This was a double-blinded, randomized controlled trial whereby 736 mothers were administered n-3 LCPUFA or control from pregnancy week 24 until 1 week after birth. We measured the number of days with gastroenteritis, number of episodes with gastroenteritis, and the risk of having a gastroenteritis episode in the first 3 years of life.RESULTS: A median reduction of 2.5 days with gastroenteritis (P = .018) was shown, corresponding to a 14% reduction in the n-3 LCPUFA group compared with controls in the first 3 years of life (P = .037). A reduction in the number of gastroenteritis episodes (P = .027) and a reduced risk of having an episode (hazard ratio, 0.80 [95% confidence interval, .66-.97]; P = .023) were also shown.CONCLUSIONS: Fish oil supplementation from the 24th week of pregnancy led to a reduction in the number of days and episodes with gastroenteritis symptoms in the first 3 years of life. The findings suggest n-3 LCPUFA supplementation as a preventive measure against gastrointestinal infections in early childhood.CLINICAL TRIALS REGISTRATION: NCT00798226.
KW - Child, Preschool
KW - Dietary Supplements
KW - Fatty Acids, Omega-3/therapeutic use
KW - Female
KW - Fish Oils/therapeutic use
KW - Gastroenteritis/prevention & control
KW - Humans
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85161687656&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab607
DO - 10.1093/infdis/jiab607
M3 - Journal article
C2 - 34927195
VL - 227
SP - 448
EP - 456
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -