Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Supplemental oxygen therapy in trauma patients: an exploratory registry-based study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Bioimpedance as a measure of fluid status in critically ill patients: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Effect of immunoglobulin G on cytokine response in necrotising soft-tissue infection: a post-hoc analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ischaemic vascular disease and long-term mortality in emergency abdominal surgical patients: A population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Phrenic Nerve Block on Severe Post-Hepatectomy Shoulder Pain: A Randomized, Double-blind, Placebo-controlled, Pilot Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Investigating the use of physical restraint of children in emergency departments: A Scandinavian survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ketamine versus propofol for rapid sequence induction in trauma patients: a retrospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Criteria-based dispatch of emergency medical services in non-traumatic subarachnoid haemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Symptoms presented during emergency telephone calls for patients with spontaneous subarachnoid haemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hemorrhage and saline resuscitation are associated with epigenetic and proteomic reprogramming in the rat lung

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Supplemental oxygen (SO) is one of the most commonly administered drugs in trauma patients and is recommended by guidelines. However, evidence supporting uniform administration is sparse, and excess oxygen use has been shown to be harmful in other patient populations. We hypothesized that SO may be harmful in patients with oxygen saturation>97%.

METHODS: Patients with available information on SO-therapy in the American Trauma Quality Improvement Program 2017 database were included. Patients were categorized into three groups according to Emergency Department (ED) oxygen saturation: 1) Saturation<94%; 2) Saturation 94-97%; 3) Saturation 98-100%. Primary outcome was in-hospital mortality with comparisons made between patients who received SO or not. Secondary outcome was acute respiratory distress syndrome (ARDS). Patients were compared after propensity score matching.

RESULTS: Overall, 864,340 patients were identified. Mean age was 47.4 ± 24.4 years and median injury severity score was 9. SO was associated with an increased risk of in-hospital mortality: (all patients: adjusted odds ratio (aOR) with 95% confidence interval (CI) 3.07 [2.92-3.22], ED saturation <94%: 2.63 [2.38-2.91], ED saturation 94%-97%: 2.71 [2.47-2.97], ED saturation >97%: 3.38 [3.16-3.61]. Same pattern was seen for in-hospital ARDS: (aOR 1.79, 95% CI [1.59-2.02], ED saturation <94%: aOR 1.75, 95% CI 1.37-2.24, ED saturation 94%-97%: aOR 1.81, 95% CI 1.43-2.29, ED saturation >97%: aOR 2.31, 95% CI 1.92-2.79).

CONCLUSION: Based on propensity matched, registry data for trauma patients, the administration of SO was associated with a higher incidence of in-hospital mortality and ARDS. The highest risk was found in patients with an ED saturation >97%.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume65
Issue number7
Pages (from-to)967-978
Number of pages12
ISSN0001-5172
DOIs
Publication statusPublished - Aug 2021

    Research areas

  • ARDS, mortality, oxygen therapy, trauma

ID: 64826622