suPAR: The unspecific marker for disease presence, severity and prognosis

Jesper Eugen-Olsen; Evangelos J Giamarellos-Bourboulis

doi:10.1016/j.ijantimicag.2015.10.011

suPAR: The unspecific marker for disease presence, severity and prognosis

Jesper Eugen-Olsen, Evangelos J Giamarellos-Bourboulis

Department of Clinical Research

31 Citations (Scopus)

596 Downloads (Pure)

Abstract

Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents a thorough analysis of the data from these studies.

Original language	English
Journal	International Journal of Antimicrobial Agents
Volume	41
Issue number	1
Pages (from-to)	s33-s34
ISSN	0924-8579
DOIs	https://doi.org/10.1016/j.ijantimicag.2015.10.011
Publication status	Published - Dec 2015

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AB - Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents a thorough analysis of the data from these studies.

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suPAR: The unspecific marker for disease presence, severity and prognosis

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