Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Impact of Lean Body Mass and Insulin Sensitivity on the IGF-1-Bone Mass Axis in Adolescence: the EPICOM study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Male fertility before and after androgen abuse

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, "Silenusvirus"

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

A major pathological feature of noninsulin-dependent diabetes (NIDDM) is defective insulin-stimulated glucose transport in skeletal muscle. When NIDDM subjects are assessed as a group, GLUT4 gene expression in skeletal muscle varies widely and is not different from that in controls. Thus, longitudinal studies are needed to assess whether changes in GLUT4 expression in muscle of NIDDM subjects could be responsible for changes in glucose disposal. The question is timely because recent studies in transgenic mice show that increasing GLUT4 expression can increase insulin-stimulated glucose uptake in vivo and in vitro. Here we use a longitudinal design to investigate the effects of 8 weeks of therapy with the sulfonylurea gliclazide on glycemic control, glucose tolerance, insulin-stimulated glucose disposal, and GLUT4 expression in muscle of 10 obese NIDDM subjects. Subjects were on a weight-maintaining diet. Gliclazide treatment results in increased serum C-peptide, decreased hemoglobin-A1c, decreased glucose excursion on glucose tolerance test, and 35% increased insulin-stimulated glucose disposal. Gliclazide therapy is not associated with any change in DNA or protein content per g muscle or any alteration in GLUT4 levels expressed either per microgram membrane protein or per DNA. In summary, the improvement in glycemic control and glucose disposal in NIDDM subjects receiving gliclazide therapy cannot be explained by increased expression of GLUT4 in muscle. Thus, therapeutic effects on insulin-stimulated glucose disposal can be achieved in NIDDM subjects without altering GLUT4 expression in muscle.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume80
Issue number1
Pages (from-to)270-5
Number of pages6
ISSN0021-972X
DOIs
Publication statusPublished - Jan 1995

    Research areas

  • Adult, Aged, Base Sequence, Diabetes Mellitus, Type 2, Female, Gliclazide, Glucose, Glucose Clamp Technique, Glucose Transporter Type 4, Humans, Longitudinal Studies, Male, Middle Aged, Molecular Sequence Data, Monosaccharide Transport Proteins, Muscle Proteins, Muscle, Skeletal, Oligonucleotide Probes, RNA, Messenger, Sulfonylurea Compounds, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.

ID: 52806124