TY - JOUR
T1 - Subcutaneous oxygen and carbon dioxide tensions during head-up tilt-induced central hypovolaemia in humans
AU - Larsen, P. N.
AU - Moesgaard, F.
AU - Madsen, P.
AU - Pedersen, M.
AU - Secher, N. H.
PY - 1996
Y1 - 1996
N2 - The effect of hypovolaemic shock on subcutaneous oxygen and carbon dioxide tensions was studied in man. Subcutaneous oxygen (Psc,O2) and carbon dioxide (Psc,CO2) tensions were monitored, during 50° head-up tilt (anti-Trendelenburg's position)-induced central hypovolaemia, in two females and eight males, using a silicone tonometer on the lateral upper aspect of the right arm. All cardiovascular variables remained stable at rest. Incremental tilting to 50° increased heart rate (HR) and mean arterial pressure (MAP) (p<0.01), while stroke volume (SV), cardiac output (CO) and central venous saturation (SvO2) decreased (p<0.05). Presyncopal symptoms appeared after 28 (8-48) min (mean and range) as HR decreased from 82 (63-108) to 52 (36-70) beats min-1 (p<0.05), MAP from 88 (61-106) to 46 (37-54) mmHg and SvO2 from 0.68 (0.56-0.76) to 0.58 (0.39-0.70) (p<0.01). On return of the tilt table to the horizontal position HR, MAP, SV, CO and SvO2 immediately re-established resting values. The Psc,O2 was 83 (72-102) mmHg at rest and during tilting it increased to 89 (82-111)mmHg followed by a decrease to 72 (58-97)mmHg (p<0.01) at the appearance of presyncopal symptoms. Psc,O2 returned to the pretilt level over 45 (30-60) min of recovery. Arterial oxygen, carbon dioxide and Psc,CO2 did not change significantly. Subcutaneous oxygen tension decreases during marked central hypovolaemia and it returns slowly to the resting level during recovery. Psc,O2 is a more sensitive marker of impaired tissue oxygenation than arterial oxygen pressure.
AB - The effect of hypovolaemic shock on subcutaneous oxygen and carbon dioxide tensions was studied in man. Subcutaneous oxygen (Psc,O2) and carbon dioxide (Psc,CO2) tensions were monitored, during 50° head-up tilt (anti-Trendelenburg's position)-induced central hypovolaemia, in two females and eight males, using a silicone tonometer on the lateral upper aspect of the right arm. All cardiovascular variables remained stable at rest. Incremental tilting to 50° increased heart rate (HR) and mean arterial pressure (MAP) (p<0.01), while stroke volume (SV), cardiac output (CO) and central venous saturation (SvO2) decreased (p<0.05). Presyncopal symptoms appeared after 28 (8-48) min (mean and range) as HR decreased from 82 (63-108) to 52 (36-70) beats min-1 (p<0.05), MAP from 88 (61-106) to 46 (37-54) mmHg and SvO2 from 0.68 (0.56-0.76) to 0.58 (0.39-0.70) (p<0.01). On return of the tilt table to the horizontal position HR, MAP, SV, CO and SvO2 immediately re-established resting values. The Psc,O2 was 83 (72-102) mmHg at rest and during tilting it increased to 89 (82-111)mmHg followed by a decrease to 72 (58-97)mmHg (p<0.01) at the appearance of presyncopal symptoms. Psc,O2 returned to the pretilt level over 45 (30-60) min of recovery. Arterial oxygen, carbon dioxide and Psc,CO2 did not change significantly. Subcutaneous oxygen tension decreases during marked central hypovolaemia and it returns slowly to the resting level during recovery. Psc,O2 is a more sensitive marker of impaired tissue oxygenation than arterial oxygen pressure.
KW - Arterial oxygen saturation
KW - Blood pressure
KW - Cardiac output
KW - Central venous pressure
KW - Heart rate
KW - Stroke volume
KW - Venous oxygen saturation
UR - http://www.scopus.com/inward/record.url?scp=0030020859&partnerID=8YFLogxK
U2 - 10.3109/00365519609088583
DO - 10.3109/00365519609088583
M3 - Journal article
C2 - 8850168
AN - SCOPUS:0030020859
SN - 0036-5513
VL - 56
SP - 17
EP - 24
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
IS - 1
ER -