Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Research output: Contribution to journalComment/debateResearchpeer-review

View graph of relations

We explored whether depressive symptoms measured three times during midlife were associated with structural brain alterations quantified using magnetic resonance imaging measurements of volume, cortical thickness, and intensity texture. In 192 men born in 1953 with depressive symptoms measured at age 51, 56, and 59 years, magnetic resonance imaging was performed at age 59. All data processing was performed using the Freesurfer software package except for the texture-scores that were computed using in-house software. Structural brain alterations and associations between depressive symptoms and brain structure outcomes were tested using Pearson's correlation, t test, and linear regression. Depressive symptoms at age 51 showed clear inverse correlations with total gray matter, pallidum, and hippocampal volume with the strongest estimate for hippocampal volume (r = -.22, p < .01). After exclusion of men (n = 3) with scores in the range of clinical depression the inverse correlation between depressive symptoms and hippocampal volume became insignificant (r = -13, p = .08). Depressive symptoms at age 59 correlated positively with hippocampal and amygdala texture-potential early markers of atrophy. Inverse relations with total gray matter and pallidum volumes lost significance when the analysis was adjusted for intracranial volume. In men, depressive symptoms at age 51 were associated with a reduced volume of the hippocampus at age 59 independent of later symptoms. Amygdala and hippocampal textures might be the early markers for brain alterations associated with depression in midlife.

Original languageEnglish
JournalHuman Brain Mapping
Volume39
Issue number4
Pages (from-to)1789-1795
ISSN1065-9471
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52397789