Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans

Kristoffer Sølvsten Burgdorf; Niels Grarup; Johanne Marie Justesen; Marie Neergaard Harder; Daniel Rinse Witte; Torben Jørgensen; Annelli Sandbæk; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen; DIAGRAM Consortium

doi:10.1371/journal.pone.0015813

Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans

Kristoffer Sølvsten Burgdorf, Niels Grarup, Johanne Marie Justesen, Marie Neergaard Harder, Daniel Rinse Witte, Torben Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Sten Madsbad, Torben Hansen, Oluf Pedersen, DIAGRAM Consortium

Endocrinology Unit

50 Citations (Scopus)

Abstract

A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes.

Original language	English
Journal	P L o S One
Volume	6
Issue number	1
Pages (from-to)	e15813
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0015813
Publication status	Published - 2011

Keywords

Case-Control Studies
Diabetes Mellitus, Type 2
Europe
European Continental Ancestry Group
Genome-Wide Association Study
Genotype
Humans
Tumor Suppressor Protein p53

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10.1371/journal.pone.0015813

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Burgdorf, K. S., Grarup, N., Justesen, J. M., Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, S., Hansen, T., Pedersen, O., & DIAGRAM Consortium (2011). Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans. P L o S One, 6(1), e15813. https://doi.org/10.1371/journal.pone.0015813

Burgdorf, KS, Grarup, N, Justesen, JM, Harder, MN, Witte, DR, Jørgensen, T, Sandbæk, A, Lauritzen, T, Madsbad, S, Hansen, T, Pedersen, O & DIAGRAM Consortium 2011, 'Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans', P L o S One, vol. 6, no. 1, pp. e15813. https://doi.org/10.1371/journal.pone.0015813

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AU - Harder, Marie Neergaard

AU - Witte, Daniel Rinse

AU - Jørgensen, Torben

AU - Sandbæk, Annelli

AU - Lauritzen, Torsten

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - DIAGRAM Consortium

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KW - Diabetes Mellitus, Type 2

KW - Europe

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Tumor Suppressor Protein p53

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Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans

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Keywords

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