Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø; Meena Shaheen Hussain; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Torben Hansen; Oluf Pedersen; Gitte Andersen

doi:10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø, Meena Shaheen Hussain, Knut Borch-Johnsen, Torben Jørgensen, Sten Madsbad, Torben Hansen, Oluf Pedersen, Gitte Andersen

Endocrinology Unit

3 Citations (Scopus)

Abstract

Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

Original language	English
Journal	Molecular Genetics and Metabolism
Volume	92
Issue number	3
Pages (from-to)	278-82
Number of pages	4
ISSN	1096-7192
DOIs	https://doi.org/10.1016/j.ymgme.2007.06.011
Publication status	Published - 2007

Keywords

Blood Glucose
Calcium-Binding Proteins
Case-Control Studies
Denmark
Diabetes Mellitus, Type 2
Dyslipidemias
Ethnic Groups
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Mitochondrial Proteins
Obesity
Polymorphism, Single Nucleotide

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10.1016/j.ymgme.2007.06.011

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Sparsø, T., Hussain, M. S., Borch-Johnsen, K., Jørgensen, T., Madsbad, S., Hansen, T., Pedersen, O., & Andersen, G. (2007). Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. Molecular Genetics and Metabolism, 92(3), 278-82. https://doi.org/10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. / Sparsø, Thomas; Hussain, Meena Shaheen; Borch-Johnsen, Knut et al.
In: Molecular Genetics and Metabolism, Vol. 92, No. 3, 2007, p. 278-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Sparsø, T, Hussain, MS, Borch-Johnsen, K, Jørgensen, T, Madsbad, S, Hansen, T, Pedersen, O & Andersen, G 2007, 'Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites', Molecular Genetics and Metabolism, vol. 92, no. 3, pp. 278-82. https://doi.org/10.1016/j.ymgme.2007.06.011

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abstract = "Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.",

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AU - Sparsø, Thomas

AU - Hussain, Meena Shaheen

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Andersen, Gitte

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AB - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

KW - Blood Glucose

KW - Calcium-Binding Proteins

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Dyslipidemias

KW - Ethnic Groups

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Mitochondrial Proteins

KW - Obesity

KW - Polymorphism, Single Nucleotide

UR - https://www.scopus.com/pages/publications/34848911646

U2 - 10.1016/j.ymgme.2007.06.011

DO - 10.1016/j.ymgme.2007.06.011

M3 - Journal article

C2 - 17681849

SN - 1096-7192

VL - 92

SP - 278

EP - 282

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 3

ER -

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

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Keywords

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