Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

Lena Sønder Snogdal, Niels Grarup, Karina Banasik, Mette Wod, Torben Jørgensen, Daniel Rinse Witte, Torsten Lauritzen, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Oluf Borbye Pedersen, Knud Bonnet Yderstræde, Henning Beck-Nielsen, Jan Erik Henriksen, Torben Hansen, Kurt Højlund

    2 Citations (Scopus)

    Abstract

    Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
    Original languageEnglish
    JournalB M C Medical Genetics
    Volume14
    Issue number1
    Pages (from-to)113
    ISSN1471-2350
    DOIs
    Publication statusPublished - 25 Oct 2013

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