Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Kristoffer Sølvsten Burgdorf; Camilla Helene Sandholt; Thomas Hempel Sparsø; Gitte Andersen; Daniel Rinse Witte; Torben Jørgensen; Anelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Sten Madsbad; Torben Hansen; Oluf Pedersen

doi:10.1530/EJE-10-0068

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

Kristoffer Sølvsten Burgdorf, Camilla Helene Sandholt, Thomas Hempel Sparsø, Gitte Andersen, Daniel Rinse Witte, Torben Jørgensen, Anelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Sten Madsbad, Torben Hansen, Oluf Pedersen

Endocrinology Unit

14 Citations (Scopus)

Abstract

Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.

Original language	English
Journal	European journal of endocrinology / European Federation of Endocrine Societies
Volume	163
Issue number	1
Pages (from-to)	81-7
Number of pages	7
DOIs	https://doi.org/10.1530/EJE-10-0068
Publication status	Published - 1 Jul 2010

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Burgdorf, K. S., Sandholt, C. H., Sparsø, T. H., Andersen, G., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Sørensen, T. I. A., Madsbad, S., Hansen, T., & Pedersen, O. (2010). Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. European journal of endocrinology / European Federation of Endocrine Societies, 163(1), 81-7. https://doi.org/10.1530/EJE-10-0068

Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. / Burgdorf, Kristoffer Sølvsten; Sandholt, Camilla Helene; Sparsø, Thomas Hempel et al.
In: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 163, No. 1, 01.07.2010, p. 81-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Burgdorf, KS, Sandholt, CH, Sparsø, TH, Andersen, G, Witte, DR, Jørgensen, T, Sandbaek, A, Lauritzen, T, Sørensen, TIA, Madsbad, S, Hansen, T & Pedersen, O 2010, 'Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes', European journal of endocrinology / European Federation of Endocrine Societies, vol. 163, no. 1, pp. 81-7. https://doi.org/10.1530/EJE-10-0068

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abstract = "Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.",

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AU - Burgdorf, Kristoffer Sølvsten

AU - Sandholt, Camilla Helene

AU - Sparsø, Thomas Hempel

AU - Andersen, Gitte

AU - Witte, Daniel Rinse

AU - Jørgensen, Torben

AU - Sandbaek, Anelli

AU - Lauritzen, Torsten

AU - Sørensen, Thorkild I A

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2010/7/1

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N2 - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.

AB - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.

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JO - European journal of endocrinology / European Federation of Endocrine Societies

JF - European journal of endocrinology / European Federation of Endocrine Societies

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Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes

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