Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Anette P Gjesing; Aneta Aleksandra Nielsen; Ivan Brandslund; Cramer Christensen; Anneli Sandbæk; Torben Jørgensen; Daniel Rinse Witte; Amélie Bonnefond; Phillippe Froguel; Torben Hansen; Oluf Pedersen

doi:10.1186/1471-2350-12-99

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Anette P Gjesing, Aneta Aleksandra Nielsen, Ivan Brandslund, Cramer Christensen, Anneli Sandbæk, Torben Jørgensen, Daniel Rinse Witte, Amélie Bonnefond, Phillippe Froguel, Torben Hansen, Oluf Pedersen

10 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.

Original language	English
Journal	B M C Medical Genetics
Volume	12
Pages (from-to)	99
ISSN	1471-2350
DOIs	https://doi.org/10.1186/1471-2350-12-99
Publication status	Published - 2011

Keywords

Case-Control Studies
Denmark
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Genotype
Glucose Tolerance Test
Hemoglobin A, Glycosylated
Hexokinase
Humans
Models, Statistical
Polymorphism, Single Nucleotide
Prevalence

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title = "Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes",

abstract = "Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.",

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doi = "10.1186/1471-2350-12-99",

language = "English",

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journal = "B M C Medical Genetics",

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T1 - Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

AU - Gjesing, Anette P

AU - Nielsen, Aneta Aleksandra

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Sandbæk, Anneli

AU - Jørgensen, Torben

AU - Witte, Daniel Rinse

AU - Bonnefond, Amélie

AU - Froguel, Phillippe

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2011

Y1 - 2011

N2 - Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.

AB - Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose- and lipid-metabolism in a Danish non-diabetic population and combine the outcome of these analyses in a meta-analysis with previously published results. Furthermore, our aim was to perform a type 2 diabetes case-control analysis and meta-analysis with two previous case-control studies.

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Genome-Wide Association Study

KW - Genotype

KW - Glucose Tolerance Test

KW - Hemoglobin A, Glycosylated

KW - Hexokinase

KW - Humans

KW - Models, Statistical

KW - Polymorphism, Single Nucleotide

KW - Prevalence

UR - https://www.scopus.com/pages/publications/79960605545

U2 - 10.1186/1471-2350-12-99

DO - 10.1186/1471-2350-12-99

M3 - Journal article

C2 - 21781351

SN - 1471-2350

VL - 12

SP - 99

JO - B M C Medical Genetics

JF - B M C Medical Genetics

ER -

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Abstract

Keywords

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