Abstract
In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.
| Original language | English |
|---|---|
| Journal | Infection and Immunity |
| Volume | 71 |
| Issue number | 5 |
| Pages (from-to) | 2970-5 |
| Number of pages | 6 |
| ISSN | 0019-9567 |
| DOIs | |
| Publication status | Published - May 2003 |
| Externally published | Yes |
Keywords
- Actins/metabolism
- Animals
- Burkholderia pseudomallei/pathogenicity
- Cell Cycle/drug effects
- Cell Line
- Cytoskeleton/drug effects
- Flow Cytometry
- GTP Phosphohydrolases/physiology
- Glycolipids/toxicity
- Mice
- Microscopy, Fluorescence
- Phagocytosis
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