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Striated muscle fiber size, composition, and capillary density in diabetes in relation to neuropathy and muscle strength

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Prediction of Excessive Weight Gain in Insulin Treated Patients with Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Christer Swan Andreassen
  • Jacob Malte Jensen
  • Johannes Jakobsen
  • Benedicte Parm Ulhøj
  • Henning Andersen
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OBJECTIVE: Diabetic polyneuropathy (DPN) leads to progressive loss of muscle strength in the lower extremities due to muscular atrophy. Changes in vascularization occur in diabetic striated muscle; however, the relationship between these changes and DPN is as yet unexplored. The aim of the present study was to evaluate histologic properties and capillarization of diabetic skeletal muscle in relation to DPN and muscle strength.

METHODS: Twenty type 1 and 20 type 2 diabetic (T1D and T2D, respectively) patients underwent biopsy of the gastrocnemic muscle, isokinetic dynamometry at the ankle, electrophysiological studies, clinical examination, and quantitative sensory examinations. Muscle biopsies were stained immunohistochemically and muscle fiber diameter, fiber type distribution, and capillary density determined. Twenty control subjects were also included in the study.

RESULTS: No relationship was found between muscle fiber diameter, muscle fiber type distribution, or capillary density and degree of neuropathy or muscle strength for either patient group. Muscle fiber diameter and the proportion of Type II fibers were greater for T1D patients than both T2D patients and controls. The T2D patients had fewer capillaries per muscle fiber than T1D patients and controls.

CONCLUSIONS: Striated muscle fiber size, muscle fiber distribution, and vascularization are unrelated to DPN and muscle strength in diabetes.

Original languageEnglish
JournalJournal of Diabetes
Issue number5
Pages (from-to)462-71
Number of pages10
Publication statusPublished - Sep 2014

ID: 44996082