Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

Bülent Kücükakin; Volkan Kocak; Jens Lykkesfeldt; Hans J Nielsen; Karin Magnussen; Jacob Rosenberg; Ismail Gögenur

doi:10.3109/00365513.2011.563789

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

Bülent Kücükakin, Volkan Kocak, Jens Lykkesfeldt, Hans J Nielsen, Karin Magnussen, Jacob Rosenberg, Ismail Gögenur

31 Citations (Scopus)

Abstract

Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days.

Original language	English
Journal	Scandinavian Journal of Clinical & Laboratory Investigation
Volume	71
Issue number	4
Pages (from-to)	299-303
Number of pages	5
ISSN	0036-5513
DOIs	https://doi.org/10.3109/00365513.2011.563789
Publication status	Published - 2011

Keywords

Adipokines
Ascorbic Acid
Biological Markers
Blood Preservation
Erythrocytes
Humans
Inflammation Mediators
Interleukin-6
Lectins
Malondialdehyde
Oxidative Stress
Time Factors
alpha-Tocopherol

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10.3109/00365513.2011.563789

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title = "Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components",

abstract = "Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days.",

keywords = "Adipokines, Ascorbic Acid, Biological Markers, Blood Preservation, Erythrocytes, Humans, Inflammation Mediators, Interleukin-6, Lectins, Malondialdehyde, Oxidative Stress, Time Factors, alpha-Tocopherol",

author = "B{\"u}lent K{\"u}c{\"u}kakin and Volkan Kocak and Jens Lykkesfeldt and Nielsen, \{Hans J\} and Karin Magnussen and Jacob Rosenberg and Ismail G{\"o}genur",

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T1 - Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

AU - Kücükakin, Bülent

AU - Kocak, Volkan

AU - Lykkesfeldt, Jens

AU - Nielsen, Hans J

AU - Magnussen, Karin

AU - Rosenberg, Jacob

AU - Gögenur, Ismail

PY - 2011

Y1 - 2011

N2 - Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days.

AB - Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells in SAG-M additive solution, by assessing biomarkers of oxidative and inflammatory stress during a storage period of 35 days.

KW - Adipokines

KW - Ascorbic Acid

KW - Biological Markers

KW - Blood Preservation

KW - Erythrocytes

KW - Humans

KW - Inflammation Mediators

KW - Interleukin-6

KW - Lectins

KW - Malondialdehyde

KW - Oxidative Stress

KW - Time Factors

KW - alpha-Tocopherol

UR - https://www.scopus.com/pages/publications/79958814965

U2 - 10.3109/00365513.2011.563789

DO - 10.3109/00365513.2011.563789

M3 - Journal article

C2 - 21385017

SN - 0036-5513

VL - 71

SP - 299

EP - 303

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 4

ER -

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

Abstract

Keywords

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