Statins and COPD: relationship with inflammation, exacerbations and mortality

Mathias Damkjær; Kjell E J Håkansson; Charlotte S Ulrik; Nina S Godtfredsen

Statins and COPD: relationship with inflammation, exacerbations and mortality

Translated title of the contribution: Statins and COPD: relationship with inflammation, exacerbations and mortality

Mathias Damkjær, Kjell E J Håkansson, Charlotte S Ulrik, Nina S Godtfredsen

Respiratory Unit

1 Citation (Scopus)

Abstract

The role of statins on the disease course of COPD is controversial. Observational studies have shown a reduction in mortality and exacerbations, but results of randomised clinical trials (RCTs) of statin treatment and its effect on adverse outcomes are conflicting. Recent meta-analyses suggest the need for further RCTs including COPD patients both with and without concurrent cardiovascular disease (CVD). As there are no known detrimental effects of statins in COPD patients, we conclude in this review, that statins should be prescribed more frequently in these patients due to the common co-morbidity with CVD.

Translated title of the contribution	Statins and COPD: relationship with inflammation, exacerbations and mortality
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	182
Issue number	23
ISSN	0041-5782
Publication status	Published - 1 Jun 2020

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title = "Statins and COPD: relationship with inflammation, exacerbations and mortality",

abstract = "The role of statins on the disease course of COPD is controversial. Observational studies have shown a reduction in mortality and exacerbations, but results of randomised clinical trials (RCTs) of statin treatment and its effect on adverse outcomes are conflicting. Recent meta-analyses suggest the need for further RCTs including COPD patients both with and without concurrent cardiovascular disease (CVD). As there are no known detrimental effects of statins in COPD patients, we conclude in this review, that statins should be prescribed more frequently in these patients due to the common co-morbidity with CVD.",

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T1 - Statins and COPD: relationship with inflammation, exacerbations and mortality

AU - Damkjær, Mathias

AU - Håkansson, Kjell E J

AU - Ulrik, Charlotte S

AU - Godtfredsen, Nina S

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The role of statins on the disease course of COPD is controversial. Observational studies have shown a reduction in mortality and exacerbations, but results of randomised clinical trials (RCTs) of statin treatment and its effect on adverse outcomes are conflicting. Recent meta-analyses suggest the need for further RCTs including COPD patients both with and without concurrent cardiovascular disease (CVD). As there are no known detrimental effects of statins in COPD patients, we conclude in this review, that statins should be prescribed more frequently in these patients due to the common co-morbidity with CVD.

AB - The role of statins on the disease course of COPD is controversial. Observational studies have shown a reduction in mortality and exacerbations, but results of randomised clinical trials (RCTs) of statin treatment and its effect on adverse outcomes are conflicting. Recent meta-analyses suggest the need for further RCTs including COPD patients both with and without concurrent cardiovascular disease (CVD). As there are no known detrimental effects of statins in COPD patients, we conclude in this review, that statins should be prescribed more frequently in these patients due to the common co-morbidity with CVD.

UR - https://www.scopus.com/pages/publications/85086298103

M3 - Tidsskriftartikel

C2 - 32515342

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 23

ER -

Statins and COPD: relationship with inflammation, exacerbations and mortality

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