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STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides

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  1. The Influence of Cyst Emptying, Lymph Node Resection and Chemotherapy on Survival in Stage IA and IC1 Epithelial Ovarian Cancer

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  2. Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer

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  3. High RRM1 Expression Is Associated with Adverse Outcome in Patients with Cisplatin/Vinorelbine-treated Malignant Pleural Mesothelioma

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  4. Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma

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  • Simon Mayland Fredholm
  • Lise Mette Gjerdrum
  • Andreas Willerslev-Olsen
  • David Leander Petersen
  • Inger Ø. Nielsen
  • Claudia-S Kauczok
  • Marion Wobser
  • Ulrik Ralfkiær
  • Charlotte M Bonefeld
  • Mariusz A Wasik
  • Thorbjørn Krejsgaard
  • Carsten Geisler
  • Elisabeth Ralfkiaer
  • Robert Gniadecki
  • Anders Woetmann
  • Niels Odum
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Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78% of patients with advanced disease displayed eosinophil infiltration, whereas this was only seen in 11% of patients with patches (p<0.01), and in 48% of those with plaque disease. Importantly, 72% of patients with positive staining for phospho-signal-transducer-and-activator-of-transcription (pY-STAT3) in malignant T-cells also stained positively for eosinophils, whereas this was only observed in 28% of pY-STAT3-negative patients (p<0.01). Notably, malignant T-cells expressed eosinophilic activation and trafficking factors: High-mobility group BOX-1 protein (HMGB1) and interleukin 5 (IL5). STAT3 siRNA profoundly inhibited IL5 but not HMGB1 expression. In conclusion, these data suggest that malignant T-cells orchestrate accumulation and activation of eosinophils supporting the notion of STAT3 being a putative target for therapy.

Original languageEnglish
JournalAnticancer Research
Volume34
Issue number10
Pages (from-to)5277-86
Number of pages10
ISSN0250-7005
Publication statusPublished - Oct 2014

ID: 44704751