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Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

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Harvard

Blümel, E, Munir Ahmad, S, Nastasi, C, Willerslev-Olsen, A, Gluud, M, Fredholm, S, Hu, T, Surewaard, BGJ, Lindahl, LM, Fogh, H, Koralov, SB, Rahbek Gjerdrum, LM, Clark, RA, Iversen, L, Krejsgaard, T, Bonefeld, CM, Geisler, C, Becker, JC, Woetmann, A, Andersen, MH, Buus, TB & Ødum, N 2020, 'Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma', OncoImmunology, vol. 9, no. 1, 1751561, pp. 1751561. https://doi.org/10.1080/2162402X.2020.1751561

APA

Blümel, E., Munir Ahmad, S., Nastasi, C., Willerslev-Olsen, A., Gluud, M., Fredholm, S., Hu, T., Surewaard, B. G. J., Lindahl, L. M., Fogh, H., Koralov, S. B., Rahbek Gjerdrum, L. M., Clark, R. A., Iversen, L., Krejsgaard, T., Bonefeld, C. M., Geisler, C., Becker, J. C., Woetmann, A., ... Ødum, N. (2020). Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology, 9(1), 1751561. [1751561]. https://doi.org/10.1080/2162402X.2020.1751561

CBE

Blümel E, Munir Ahmad S, Nastasi C, Willerslev-Olsen A, Gluud M, Fredholm S, Hu T, Surewaard BGJ, Lindahl LM, Fogh H, Koralov SB, Rahbek Gjerdrum LM, Clark RA, Iversen L, Krejsgaard T, Bonefeld CM, Geisler C, Becker JC, Woetmann A, Andersen MH, Buus TB, Ødum N. 2020. Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology. 9(1):1751561. https://doi.org/10.1080/2162402X.2020.1751561

MLA

Vancouver

Author

Blümel, Edda ; Munir Ahmad, Shamaila ; Nastasi, Claudia ; Willerslev-Olsen, Andreas ; Gluud, Maria ; Fredholm, Simon ; Hu, Tengpeng ; Surewaard, Bas G J ; Lindahl, Lise M ; Fogh, Hanne ; Koralov, Sergei B ; Rahbek Gjerdrum, Lise Mette ; Clark, Rachael A ; Iversen, Lars ; Krejsgaard, Thorbjørn ; Bonefeld, Charlotte Menné ; Geisler, Carsten ; Becker, Jürgen C ; Woetmann, Anders ; Andersen, Mads Hald ; Buus, Terkild Brink ; Ødum, Niels. / Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. In: OncoImmunology. 2020 ; Vol. 9, No. 1. pp. 1751561.

Bibtex

@article{ec1754e1d8aa486ea6359ca822547677,
title = "Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma",
abstract = "Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and S{\'e}zary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.",
keywords = "Alpha-toxin, CD8 T cells, CTCL, cytotoxicity, Staphylococcus aureus",
author = "Edda Bl{\"u}mel and {Munir Ahmad}, Shamaila and Claudia Nastasi and Andreas Willerslev-Olsen and Maria Gluud and Simon Fredholm and Tengpeng Hu and Surewaard, {Bas G J} and Lindahl, {Lise M} and Hanne Fogh and Koralov, {Sergei B} and {Rahbek Gjerdrum}, {Lise Mette} and Clark, {Rachael A} and Lars Iversen and Thorbj{\o}rn Krejsgaard and Bonefeld, {Charlotte Menn{\'e}} and Carsten Geisler and Becker, {J{\"u}rgen C} and Anders Woetmann and Andersen, {Mads Hald} and Buus, {Terkild Brink} and Niels {\O}dum",
note = "{\textcopyright} 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2020",
doi = "10.1080/2162402X.2020.1751561",
language = "English",
volume = "9",
pages = "1751561",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "1",

}

RIS

TY - JOUR

T1 - Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

AU - Blümel, Edda

AU - Munir Ahmad, Shamaila

AU - Nastasi, Claudia

AU - Willerslev-Olsen, Andreas

AU - Gluud, Maria

AU - Fredholm, Simon

AU - Hu, Tengpeng

AU - Surewaard, Bas G J

AU - Lindahl, Lise M

AU - Fogh, Hanne

AU - Koralov, Sergei B

AU - Rahbek Gjerdrum, Lise Mette

AU - Clark, Rachael A

AU - Iversen, Lars

AU - Krejsgaard, Thorbjørn

AU - Bonefeld, Charlotte Menné

AU - Geisler, Carsten

AU - Becker, Jürgen C

AU - Woetmann, Anders

AU - Andersen, Mads Hald

AU - Buus, Terkild Brink

AU - Ødum, Niels

N1 - © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2020

Y1 - 2020

N2 - Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.

AB - Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.

KW - Alpha-toxin

KW - CD8 T cells

KW - CTCL

KW - cytotoxicity

KW - Staphylococcus aureus

UR - http://www.scopus.com/inward/record.url?scp=85083570939&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2020.1751561

DO - 10.1080/2162402X.2020.1751561

M3 - Journal article

C2 - 32363124

VL - 9

SP - 1751561

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 1

M1 - 1751561

ER -

ID: 61350348