Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Standard complication screening information can be used for risk assessment for first time foot ulcer among patients with type 1 and type 2 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Work matters: Diabetes and worklife in the second diabetes attitudes, wishes and needs (DAWN2) study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Exercise training is associated with reduced pains from the musculoskeletal system in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association of the blood eosinophil count with end-organ symptoms

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. In Reply

    Research output: Contribution to journalLetterResearchpeer-review

  3. Labour market attachment after mild traumatic brain injury: nationwide cohort study with 5-year register follow-up in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: Diabetic foot ulcer (DFU) is a major complication of both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D); however research into risk factors for DFU does not separate between these two types. The purpose of the present investigation was to identify risk factors for development of first time DFU (FTDFU) over a period of 15 years in patients with T1D and T2D separately.

METHODS: This retrospective cohort study included 25,220 feet from 5588 patients with T1D and 7113 patients with T2D treated in the period 2001-2015. Data on baseline characteristics and comorbidities were collected from electronic patient records. Influences of various risk factors for the development of FTDFU were assessed by hazard ratios (HR) from Cox proportional hazard regression models on time from enrolment to FTDFU diagnosis or end-of-follow-up.

RESULTS: In T1D independent risk factors were male sex, age >60 years, high HbA1c, long diabetes duration, history of cardiovascular disease, macro-albuminuria, decreased visual acuity, advanced diabetic retinopathy, decreased/absent vibration sense, presence of patient reported symptoms of neuropathy, and absence of foot pulses. In T2D the independent risk factors were the same except age >60 years, a history of cardiovascular disease, and long diabetes duration.

CONCLUSIONS: This study documents that much of the standard clinical information obtained as part of the routine follow-up are also independent risk factors for development of FTDFU. This may be used to create a basis for in which patient and when prevention should be started.

Original languageEnglish
JournalDiabetes Research and Clinical Practice
Volume151
Pages (from-to)177-186
Number of pages10
ISSN0168-8227
DOIs
Publication statusPublished - May 2019

    Research areas

  • Complications, Diabetic foot ulcers, Foot ulcers, Type 1 Diabetes, Type 2 Diabetes

ID: 57291512