Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Stability and development of psychotic symptoms and the use of antipsychotic medication - long-term follow-up

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Visual attention in adults with attention-deficit/hyperactivity disorder before and after stimulant treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cognitive functioning following discontinuation of antipsychotic medication. A naturalistic sub-group analysis from the OPUS II trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Rumination-focused cognitive behaviour therapy for non-responsive chronic depression: an uncontrolled group study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Birth dimensions, severe mental illness and risk of type 2 diabetes in a cohort of Danish men born in 1953

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Few studies have evaluated the development in the use of antipsychotic medication and psychotic symptoms in patients with first-episode psychosis on a long-term basis. Our objective was to investigate how psychotic symptoms and the use of antipsychotic medication changed over a 10-year period in a cohort of patients with first-episode psychosis.

METHOD: The study is a longitudinal prospective cohort study over 10 years with follow-ups at years 1, 2, 5 and 10. A total of 496 patients with first-episode psychosis were included in a multi-centre study initiated between 1998 and 2000 in Copenhagen and Aarhus, Denmark.

RESULTS: At all follow-ups, a large proportion (20-30%) of patients had remission of psychotic symptoms without use of antipsychotic medication at the time of the follow-up. Patients who were in this group at the 5-year follow-up had an 87% [95% confidence interval (CI) 77-96%] chance of being in the same group at the 10-year follow-up. This stability was also the case for patients who had psychotic symptoms and were treated with antipsychotic medication at year 5, where there was a 67% (95% CI 56-78%) probability of being in this group at the consecutive follow-up.

CONCLUSIONS: A large group of patients with psychotic illness were in remission without the use of antipsychotic medication, peaking at year 10. Overall there was a large degree of stability in disease courses over the 10-year period. These results suggest that the long-term outcome of psychotic illness is heterogeneous and further investigation on a more individualized approach to long-term treatment is needed.

Original languageEnglish
JournalPsychological Medicine
Volume47
Issue number12
Pages (from-to)2118-2129
Number of pages12
ISSN0033-2917
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article

ID: 51693664