Abstract
PURPOSE: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats.
METHODS: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs).
RESULTS: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep.
CONCLUSIONS: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.
| Original language | English |
|---|---|
| Journal | Epilepsia |
| Volume | 46 |
| Issue number | 6 |
| Pages (from-to) | 934-8 |
| Number of pages | 5 |
| ISSN | 0013-9580 |
| DOIs | |
| Publication status | Published - Jun 2005 |
Keywords
- Animals
- Cerebral Cortex/physiopathology
- Disease Models, Animal
- Electric Wiring
- Electrodes, Implanted
- Electroencephalography
- Epilepsy, Temporal Lobe/pathology
- Hypothalamus/pathology
- Male
- Rats
- Rats, Wistar
- Seizures/etiology
- Sleep Disorders, Circadian Rhythm/physiopathology
- Sleep Stages/physiology
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