Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Splenomegaly - Diagnostic validity, work-up, and underlying causes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Kinetics of the soluble urokinase plasminogen activator receptor (suPAR) in cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence, prevalence and risk factors for hepatitis C in Danish prisons

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. l-Carnitine Improves Skeletal Muscle Fat Oxidation in Primary Carnitine Deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Osteogenesis imperfecta and the teeth, eyes, and ears-a study of non-skeletal phenotypes in adults

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Our aim was to assess the validity of the ICD-10 code for splenomegaly in the Danish National Registry of Patients (DNRP), as well as to investigate which underlying diseases explained the observed splenomegaly.

BACKGROUND: Splenomegaly is a common finding in patients referred to an internal medical department and can be caused by a large spectrum of diseases, including haematological diseases and liver cirrhosis. However, some patients remain without a causal diagnosis, despite extensive medical work-up.

PATIENTS AND METHODS: We identified 129 patients through the DNRP, that had been given the ICD-10 splenomegaly diagnosis code in 1994-2013 at Odense University Hospital, Denmark, excluding patients with prior splenomegaly, malignant haematological neoplasia or liver cirrhosis. Medical records were reviewed for validity of the splenomegaly diagnosis, diagnostic work-up, and the underlying disease was determined. The positive predictive value (PPV) with 95% confidence interval (CI) was calculated for the splenomegaly diagnosis code. Patients with idiopathic splenomegaly in on-going follow-up were also invited to be investigated for Gaucher disease.

RESULTS: The overall PPV was 92% (95% CI: 85, 96). Haematological diseases were the underlying causal diagnosis in 39%; hepatic diseases in 18%, infectious disease in 10% and other diseases in 8%. 25% of patients with splenomegaly remained without a causal diagnosis. Lymphoma was the most common haematological causal diagnosis and liver cirrhosis the most common hepatic causal diagnosis. None of the investigated patients with idiopathic splenomegaly had Gaucher disease.

CONCLUSION: Our findings show that the splenomegaly diagnosis in the DNRP is valid and can be used in registry-based studies. However, because of suspected significant under-coding, it should be considered if supplementary data sources should be used in addition, in order to attain a more representative population. Haematological diseases were the most common cause, however in a large fraction of patients no causal diagnosis was found.

Original languageEnglish
JournalP L o S One
Issue number11
Pages (from-to)e0186674
Publication statusPublished - 2017

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Denmark, Female, Humans, Infant, Infant, Newborn, International Classification of Diseases, Male, Middle Aged, Registries, Sensitivity and Specificity, Splenomegaly, Young Adult, Journal Article

ID: 52736917