Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Spinal cord atrophy in anterior-posterior direction reflects impairment in multiple sclerosis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Prevention after stroke: A quality assurance study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Does continuous electroencephalography influence therapeutic decisions in neurocritical care?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effect and efficacy of lifestyle interventions as secondary prevention

    Research output: Contribution to journalReviewResearchpeer-review

  5. Prevalence and risk of occult cancer in stroke

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ocrelizumab treatment in multiple sclerosis: A Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Can topical application of numbing cream improve the efficacy of sham TDCS?

    Research output: Contribution to conferencePosterResearch

View graph of relations

OBJECTIVE: To investigate how atrophy is distributed over the cross section of the upper cervical spinal cord and how this relates to functional impairment in multiple sclerosis (MS).

METHODS: We analysed the structural brain MRI scans of 54 patients with relapsing-remitting MS (n=22), primary progressive MS (n=9), secondary progressive MS (n=23) and 23 age- and sex-matched healthy controls. We measured the cross-sectional area (CSA), left-right width (LRW) and anterior-posterior width (APW) of the spinal cord at the segmental level C2. We tested for a nonparametric linear relationship between these atrophy measures and clinical impairments as reflected by the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Impairment Scale (MSIS).

RESULTS: In patients with MS, CSA and APW but not LRW were reduced compared to healthy controls (P<.02) and showed significant correlations with EDSS, MSIS and specific MSIS subscores.

CONCLUSION: In patients with MS, atrophy of the upper cervical cord is most evident in the antero-posterior direction. As APW of the cervical cord can be readily derived from standard structural MRI of the brain, APW constitutes a clinically useful neuroimaging marker of disease-related neurodegeneration in MS.

Original languageEnglish
JournalActa Neurologica Scandinavica
Volume136
Issue number4
Pages (from-to)330-337
ISSN0001-6314
DOIs
Publication statusPublished - 1 Oct 2017

ID: 49631761