SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization

Y Yonekura; S Nishizawa; Thomas Søgaard Mukai; Terry Fujita; H Fukuyama; M Ishikawa; H Kikuchi; J Konishi; A R Andersen; N A Lassen

doi:10.1038/jcbfm.1988.36

SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization

Y Yonekura, S Nishizawa, Thomas Søgaard Mukai, Terry Fujita, H Fukuyama, M Ishikawa, H Kikuchi, J Konishi, A R Andersen, N A Lassen

Department of Clinical Physiology and Nuclear Medicine

93 Citations (Scopus)

Abstract

In order to validate the use of technetium-99m-d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET) using the oxygen-15 CO2 inhalation technique. Although HM-PAO SPECT and rCBF PET images showed a similar distribution pattern the HM-PAO SPECT image showed less contrast between high and low activity flow regions than the rCBF image and a nonlinear relationship between HM-PAO activity and rCBF was shown. Based on the assumption of flow-dependent backdiffusion of HM-PAO from the brain, we applied a "linearization algorithm" to correct the HM-PAO SPECT images. The corrected HM-PAO SPECT images revealed a good linear correlation with rCBF (r = 0.901, p less than 0.001). The results indicated HM-PAO can be used as a flow tracer with SPECT after proper correction.

Original language	English
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	8
Issue number	6
Pages (from-to)	S82-9
ISSN	0271-678X
DOIs	https://doi.org/10.1038/jcbfm.1988.36
Publication status	Published - Dec 1988

Keywords

Adult
Brain
Cerebrovascular Circulation
Cerebrovascular Disorders
Female
Humans
Male
Middle Aged
Models, Cardiovascular
Organometallic Compounds
Oximes
Technetium
Technetium Tc 99m Exametazime
Tomography, Emission-Computed

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10.1038/jcbfm.1988.36

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Yonekura, Y., Nishizawa, S., Mukai, T. S., Fujita, T., Fukuyama, H., Ishikawa, M., Kikuchi, H., Konishi, J., Andersen, A. R., & Lassen, N. A. (1988). SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization. Journal of Cerebral Blood Flow and Metabolism, 8(6), S82-9. https://doi.org/10.1038/jcbfm.1988.36

SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization. / Yonekura, Y; Nishizawa, S; Mukai, Thomas Søgaard et al.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 8, No. 6, 12.1988, p. S82-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Yonekura, Y, Nishizawa, S, Mukai, TS, Fujita, T, Fukuyama, H, Ishikawa, M, Kikuchi, H, Konishi, J, Andersen, AR & Lassen, NA 1988, 'SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization', Journal of Cerebral Blood Flow and Metabolism, vol. 8, no. 6, pp. S82-9. https://doi.org/10.1038/jcbfm.1988.36

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abstract = "In order to validate the use of technetium-99m-d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET) using the oxygen-15 CO2 inhalation technique. Although HM-PAO SPECT and rCBF PET images showed a similar distribution pattern the HM-PAO SPECT image showed less contrast between high and low activity flow regions than the rCBF image and a nonlinear relationship between HM-PAO activity and rCBF was shown. Based on the assumption of flow-dependent backdiffusion of HM-PAO from the brain, we applied a {"}linearization algorithm{"} to correct the HM-PAO SPECT images. The corrected HM-PAO SPECT images revealed a good linear correlation with rCBF (r = 0.901, p less than 0.001). The results indicated HM-PAO can be used as a flow tracer with SPECT after proper correction.",

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AU - Yonekura, Y

AU - Nishizawa, S

AU - Mukai, Thomas Søgaard

AU - Fujita, Terry

AU - Fukuyama, H

AU - Ishikawa, M

AU - Kikuchi, H

AU - Konishi, J

AU - Andersen, A R

AU - Lassen, N A

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N2 - In order to validate the use of technetium-99m-d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET) using the oxygen-15 CO2 inhalation technique. Although HM-PAO SPECT and rCBF PET images showed a similar distribution pattern the HM-PAO SPECT image showed less contrast between high and low activity flow regions than the rCBF image and a nonlinear relationship between HM-PAO activity and rCBF was shown. Based on the assumption of flow-dependent backdiffusion of HM-PAO from the brain, we applied a "linearization algorithm" to correct the HM-PAO SPECT images. The corrected HM-PAO SPECT images revealed a good linear correlation with rCBF (r = 0.901, p less than 0.001). The results indicated HM-PAO can be used as a flow tracer with SPECT after proper correction.

AB - In order to validate the use of technetium-99m-d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET) using the oxygen-15 CO2 inhalation technique. Although HM-PAO SPECT and rCBF PET images showed a similar distribution pattern the HM-PAO SPECT image showed less contrast between high and low activity flow regions than the rCBF image and a nonlinear relationship between HM-PAO activity and rCBF was shown. Based on the assumption of flow-dependent backdiffusion of HM-PAO from the brain, we applied a "linearization algorithm" to correct the HM-PAO SPECT images. The corrected HM-PAO SPECT images revealed a good linear correlation with rCBF (r = 0.901, p less than 0.001). The results indicated HM-PAO can be used as a flow tracer with SPECT after proper correction.

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KW - Organometallic Compounds

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KW - Technetium Tc 99m Exametazime

KW - Tomography, Emission-Computed

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SPECT with [99mTc]-d,l-hexamethyl-propylene amine oxime (HM-PAO) compared with regional cerebral blood flow measured by PET: effects of linearization

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