Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

Research output: Contribution to journalJournal articleResearchpeer-review

  1. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Efficacy of a second interleukin 17 inhibitor in patients with psoriasis: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Treatment of Widespread Eosinophilic Cellulitis (Wells' Syndrome) with Benralizumab

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combine advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantify 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe the quantitative distribution of structural proteins, known and previously undescribed proteins specific to cellular subsets and those with specialized immunological functions such as cytokines and chemokines. We anticipate that this proteomic atlas of human skin will become an essential community resource for basic and translational research ( https://skin.science/ ).

Original languageEnglish
JournalNature Communications
Volume11
Issue number1
Pages (from-to)5587
ISSN2041-1723
DOIs
Publication statusPublished - 5 Nov 2020

ID: 61312003