Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sources of variability of resting cerebral blood flow in healthy subjects: a study using (133)Xe SPECT measurements

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. False positive rates in positron emission tomography (PET) voxelwise analyses

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Investigation of cortical thickness and volume during spontaneous attacks of migraine without aura: a 3-Tesla MRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Measurements of cerebral blood flow (CBF) show large variability among healthy subjects. The aim of the present study was to investigate the relative effect of established factors influencing CBF on the variability of resting CBF. We retrospectively analyzed spontaneous variability in 430 CBF measurements acquired in 152 healthy, young subjects using (133)Xe single-photon emission computed tomography. Cerebral blood flow was correlated positively with both end-tidal expiratory PCO2 (PETCO2) and female gender and inversely with hematocrit (Hct). Between- and within-subject CO2 reactivity was not significantly different. Including PETCO2, Hct and gender in the model reduced between-subject and within-subject variance by 14% and 13.5%, respectively. Within-subject variability was mainly influenced by PETCO2 and between-subject variability mostly by Hct, whereas gender appeared to be of little added value when Hct was also accounted for. The present study confirms large between-subject variability in CBF measurements and that gender, Hct, and PETCO2 explain only a small part of this variability. This implies that a large fraction of CBF variability may be due to unknown factors such as differences in neuron density or metabolism that could be subject for further studies.
Original languageEnglish
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number5
Pages (from-to)787-92
Number of pages6
ISSN0271-678X
DOIs
Publication statusPublished - May 2013

ID: 38611522