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Soluble urokinase plasminogen activator receptor is linearly associated with dietary quality and predicts mortality

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@article{2d4679a4c6674645b5ac4f4a8c23f120,
title = "Soluble urokinase plasminogen activator receptor is linearly associated with dietary quality and predicts mortality",
abstract = "Chronic inflammation is associated with disease risk and mortality in the general population. Soluble urokinase plasminogen activator receptor (suPAR) is a stable marker of chronic inflammation, and a higher serum-concentration of suPAR is found in individuals with an unhealthy lifestyle such as smoking. This article investigates the association between suPAR and dietary quality measured with the dietary quality score (DQS). The DQS is an index of the overall quality of an individual's dietary habits assessed through a self-administered FFQ. Furthermore, this article investigates the association of both suPAR and the DQS with CVD risk and mortality in the general Danish population. We analysed 5347 individuals aged 30-60 years from the Danish Inter99 study cohort. Multiple linear regression analyses showed a linear inverse association between the DQS and suPAR (P=0·0005). Cox regression analyses showed an 18 (95 {\%} CI 9, 26) {\%} increase in the risk of death from any cause with each 1 ng/ml increase in suPAR. We found no significant association between the DQS and the mortality (hazard ratio: 1·16, 95 {\%} CI 0·79, 1·69). All analyses were adjusted for demographics and lifestyle factors. The association between the DQS and suPAR on the one hand and suPAR and mortality on the other supports the argument that low dietary quality may constitute a health risk through its influence on chronic inflammation. Future research should examine whether suPAR is modifiable through changes in dietary habits.",
keywords = "Biomarkers, Dietary quality, Epidemiological studies, Inflammation, Soluble urokinase plasminogen activator receptor",
author = "T{\"o}rnkvist, {Peter B S} and Haupt, {Thomas H} and Rasmussen, {Line J H} and Steen Ladelund and Ulla Toft and Charlotta Pisinger and Jesper Eugen-Olsen",
year = "2019",
month = "3",
doi = "10.1017/S0007114518003720",
language = "English",
volume = "121",
pages = "699--708",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Soluble urokinase plasminogen activator receptor is linearly associated with dietary quality and predicts mortality

AU - Törnkvist, Peter B S

AU - Haupt, Thomas H

AU - Rasmussen, Line J H

AU - Ladelund, Steen

AU - Toft, Ulla

AU - Pisinger, Charlotta

AU - Eugen-Olsen, Jesper

PY - 2019/3

Y1 - 2019/3

N2 - Chronic inflammation is associated with disease risk and mortality in the general population. Soluble urokinase plasminogen activator receptor (suPAR) is a stable marker of chronic inflammation, and a higher serum-concentration of suPAR is found in individuals with an unhealthy lifestyle such as smoking. This article investigates the association between suPAR and dietary quality measured with the dietary quality score (DQS). The DQS is an index of the overall quality of an individual's dietary habits assessed through a self-administered FFQ. Furthermore, this article investigates the association of both suPAR and the DQS with CVD risk and mortality in the general Danish population. We analysed 5347 individuals aged 30-60 years from the Danish Inter99 study cohort. Multiple linear regression analyses showed a linear inverse association between the DQS and suPAR (P=0·0005). Cox regression analyses showed an 18 (95 % CI 9, 26) % increase in the risk of death from any cause with each 1 ng/ml increase in suPAR. We found no significant association between the DQS and the mortality (hazard ratio: 1·16, 95 % CI 0·79, 1·69). All analyses were adjusted for demographics and lifestyle factors. The association between the DQS and suPAR on the one hand and suPAR and mortality on the other supports the argument that low dietary quality may constitute a health risk through its influence on chronic inflammation. Future research should examine whether suPAR is modifiable through changes in dietary habits.

AB - Chronic inflammation is associated with disease risk and mortality in the general population. Soluble urokinase plasminogen activator receptor (suPAR) is a stable marker of chronic inflammation, and a higher serum-concentration of suPAR is found in individuals with an unhealthy lifestyle such as smoking. This article investigates the association between suPAR and dietary quality measured with the dietary quality score (DQS). The DQS is an index of the overall quality of an individual's dietary habits assessed through a self-administered FFQ. Furthermore, this article investigates the association of both suPAR and the DQS with CVD risk and mortality in the general Danish population. We analysed 5347 individuals aged 30-60 years from the Danish Inter99 study cohort. Multiple linear regression analyses showed a linear inverse association between the DQS and suPAR (P=0·0005). Cox regression analyses showed an 18 (95 % CI 9, 26) % increase in the risk of death from any cause with each 1 ng/ml increase in suPAR. We found no significant association between the DQS and the mortality (hazard ratio: 1·16, 95 % CI 0·79, 1·69). All analyses were adjusted for demographics and lifestyle factors. The association between the DQS and suPAR on the one hand and suPAR and mortality on the other supports the argument that low dietary quality may constitute a health risk through its influence on chronic inflammation. Future research should examine whether suPAR is modifiable through changes in dietary habits.

KW - Biomarkers

KW - Dietary quality

KW - Epidemiological studies

KW - Inflammation

KW - Soluble urokinase plasminogen activator receptor

UR - http://www.scopus.com/inward/record.url?scp=85063447039&partnerID=8YFLogxK

U2 - 10.1017/S0007114518003720

DO - 10.1017/S0007114518003720

M3 - Journal article

VL - 121

SP - 699

EP - 708

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 6

ER -

ID: 56200992