Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Søren Lindberg; Sune H Pedersen; Rasmus Mogelvang; Søren Galatius; Allan Flyvbjerg; Jan Skov Jensen; Mette Bjerre

doi:10.1016/j.ahj.2012.08.018

Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Søren Lindberg, Sune H Pedersen, Rasmus Mogelvang, Søren Galatius, Allan Flyvbjerg, Jan Skov Jensen, Mette Bjerre

26 Citations (Scopus)

Abstract

The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).

Original language	English
Journal	American Heart Journal
Volume	164
Issue number	5
Pages (from-to)	786-92
Number of pages	7
ISSN	0002-8703
DOIs	https://doi.org/10.1016/j.ahj.2012.08.018
Publication status	Published - 2012

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Lindberg, S., Pedersen, S. H., Mogelvang, R., Galatius, S., Flyvbjerg, A., Jensen, J. S., & Bjerre, M. (2012). Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. American Heart Journal, 164(5), 786-92. https://doi.org/10.1016/j.ahj.2012.08.018

Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. / Lindberg, Søren; Pedersen, Sune H; Mogelvang, Rasmus et al.
In: American Heart Journal, Vol. 164, No. 5, 2012, p. 786-92.

Research output: Contribution to journal › Journal article › Research › peer-review

Lindberg, S, Pedersen, SH, Mogelvang, R , Galatius, S, Flyvbjerg, A, Jensen, JS & Bjerre, M 2012, 'Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention', American Heart Journal, vol. 164, no. 5, pp. 786-92. https://doi.org/10.1016/j.ahj.2012.08.018

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abstract = "The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).",

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AU - Mogelvang, Rasmus

AU - Galatius, Søren

AU - Flyvbjerg, Allan

AU - Jensen, Jan Skov

AU - Bjerre, Mette

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AB - The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).

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U2 - 10.1016/j.ahj.2012.08.018

DO - 10.1016/j.ahj.2012.08.018

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JF - American Heart Journal

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ER -

Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Abstract

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