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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein-Barr virus encephalitis with lesion of sleep-wake regulation system: a case report

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  1. Changes in effort-reward imbalance at work and risk of onset of sleep disturbances in a population-based cohort of workers in Denmark

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  2. Long-term health and socioeconomic outcome of obstructive sleep apnea in children and adolescents

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  3. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

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  1. Brain tumours in children and adolescents may affect the circadian rhythm and quality of life

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  2. A novel homoplasmic mt-tRNAGlu m.14701C>T variant presenting with a partially reversible infantile respiratory chain deficiency

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We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABAB receptors involved in the initiation and maintenance of sleep.

Original languageEnglish
JournalSleep Medicine
Volume62
Pages (from-to)29-31
Number of pages3
ISSN1389-9457
DOIs
Publication statusPublished - 2019

ID: 58993680